Latin america genomics of breast cancer risk study (LAGENO-BCR)
Active Project Grant Awarded Last action
- Award ID
- R01CA286650
- Recipient
-
University Of California, Davis UEI TX2DAGQPENZ5
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $3,261,461
Award facts
- Assistance listing
- 93.393 Cancer Cause and Prevention Research
- Completion date 43% complete
- Place of performance
- Davis, CA, USA
Award details come from USAspending.gov.
Description
- Abstract
- Breast cancer is a leading cause of death in the U.S. And a major public health burden as one woman out of eight will receive a diagnosis in her lifetime. Advances in DNA genotyping and sequencing technologies have led to the identification of >300 germline variants that contribute to breast cancer risk. However, as of today, large 'omics' studies include women of mostly european ancestry even though preliminary evidence indicates that there is a clear benefit in studying genetically diverse samples. A genome wide association study (GWAS) in hispanic/latina (H/L) women with one tenth of the number of individuals included in previous studies led to the discovery of protective variants only present in populations that have indigenous american ancestry. These variants significantly add to the predictive accuracy of breast cancer polygenic risk scores (PRS). H/L represent 16% of the U.S. Population and in some states, up to 37%. To address the lack of H/L representation in genomics studies, we have created the latin america genomics of breast cancer (LAGENO-BC) consortium, which includes ~28,500 latin american breast cancer patients and ~32,600 unaffected women from 11 different countries and the U.S. Diaspora. Our goal is to study the latin american-specific genetic architecture of breast cancer and develop predictive models that account for variation by ancestry and geography. By combining existing studies, LAGENO-BC quadruples the prior H/L BC GWAS sample size and consequently, provides the power required for the discovery of additional variants contributing to breast cancer risk and for improving the predictive power of PRS for risk stratification in those populations. In the first aim, we propose to discover susceptibility loci and genes associated with breast cancer in H/LS by conducting GWAS and ancestry-matched multi-tissue model-based transcriptome wide association studies with readily available RNA sequence data (TWASS). These analyses will be repeated for overall risk and subtype-specific risk. In the second aim, we will use known and new genetic risk variants to improve breast cancer risk prediction using ancestry-aware approaches and integrating existing models based on non-genetic risk factors. This work is expected to result in the discovery of new risk variants that are especially relevant to populations with an admixed indigenous american ancestral background. In addition, utilizing ancestry-matched and multi-tissue models for twas, new associations linked to ancestry- specific and tissue-specific eqtls are expected to be uncovered. IT is also expected that PRS scores that incorporate H/LS variants and assess regional and ancestry heterogeneity will be more predictive than a one-size-fits-all approach. Beyond the proposed work in this application, LAGENO-BC is building up a resource that will serve as a foundation for future collaborative studies addressing a broad range of scientific questions related to breast cancer genetics in H/L populations.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $732,635 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $22,140 | |
| Amendment | $46,801 | |
| Amendment | $8,640 | |
| Amendment | $11,664 | |
| Amendment | $46,801 | |
| Amendment | $22,140 | |
| Amendment | $11,664 | |
| Amendment | $8,640 | |
| Amendment | $8,640 | |
| Amendment | $8,640 | |
| Amendment | $730,089 | |
| Amendment | $730,089 | |
| Original award | $872,878 |
Show all 16
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Fundacao Antonio Prudente | $46,801 | |
| Centro Comprensivo De Cancer De La Universidad De Puerto Rico | $453,259 | |
| Rutgers The State University Of New Jersey | $39,732 | |
| Beckman Research Institute Of The City Of Hope | $80,618 |
Quick answers
Who received award R01CA286650?
R01CA286650 was awarded to University Of California, Davis by National Cancer Institute (National Institutes of Health) on September 1, 2024.
How much is award R01CA286650 worth?
$3,261,461 has been obligated on R01CA286650.
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