Project Grant R01CA285566

Award Date 7/2/24
Completion Date 6/30/29
Dollars Obligated $577K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Atlanta, GA 30322, USA
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This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $576,659 to Emory University to investigate tumor and host immune signatures associated with disparities in outcomes following GD2 immunotherapy in neuroblastoma patients. The key objectives are to:

  1. Perform tumor-based single cell genomic, proteomic, and functional investigations before and after chemoimmunotherapy to determine tumor immune microenvironment markers influencing event-free survival (EFS) and overall survival (OS).

  2. Conduct immunophenotyping and functional assays to define peripheral host immune markers influencing EFS and OS.

  3. Explore associations between tumor/host immune landscapes and parent-reported race, adverse social determinants of health, child genetic ancestry, and clinical outcomes.

The grant includes sub-awards to Dana-Farber Cancer Institute ($107,231) and University of Florida ($100,216) to support specific research activities. The project period runs from Jul 2, 2024 to Jun 30, 2029.

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