Targeting circrna translation in glioblastoma
Active Project Grant Awarded Last action
- Award ID
- R01CA278783
- Recipient
-
Greater LOS Angeles Veterans Research And Education Foundation UEI CC78FD4FHVN1
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,850,335
Award facts
- Assistance listing
- 93.395 Cancer Treatment Research
- Completion date 53% complete
- Place of performance
- California, USA
Award details come from USAspending.gov.
Description
- Abstract
- Glioblastomas are highly malignant and invasive, making these neoplasms extremely difficult to surgically resect and these properties often result in tumors which are refractory to standard chemotherapeutic therapies. Unfortunately monotherapies targeting known drivers of glioblastomas such as hyperactive egfr and C-met rtks have proven to be ineffective suggesting redundant mechanisms of activation. We have identified circular RNA-derived proteins which are overexpressed in glioblastoma and these novel products are capable of stimulating receptor tyrosine kinase activity leading to enhanced proliferation, mobility and invasive characteristics. In this application we propose to 1.) determine the mechanism(S) of circ-HGF mediated activation of C-met in glioblastoma, 2.) clarify the role of PKA/PTBP1 signaling in the regulation of circ-HGF and circ-E-CAD translation initiation and expression in GBM, 3.) evaluate a novel small molecule inhibitor of circ-HGF and circ-E-CAD ires-dependent translation in orthotopic GBM PDX models. We also propose to investigate and chemically modify the inhibitor to build in desired anti-glioblastoma effects.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $313,616 | |
| Amendment | $31,361 | |
| Amendment | $282,255 | |
| Amendment | $282,255 | |
| Amendment | $313,616 | |
| Amendment | $313,616 | |
| Original award | $313,616 |
Quick answers
Who received award R01CA278783?
R01CA278783 was awarded to Greater LOS Angeles Veterans Research And Education Foundation by National Cancer Institute (National Institutes of Health) on March 1, 2024.
How much is award R01CA278783 worth?
$1,850,335 has been obligated on R01CA278783.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award