Implementing and evaluating the cancer tracking system (catsystem): a systems level intervention to improve cervical cancer screening, treatment referral and follow up in kenya

Active Project Grant Awarded Last action

Award ID
R01CA278617
Recipient
Awarding agency
Obligated
$2,721,015

Award facts

Assistance listing
93.393 Cancer Cause and Prevention Research
Completion date 65% complete
Place of performance
Kansas City, KS 66160, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
In kenya, cervical cancer (CC) contributes to over 80% of female reproductive-tract cancers,4 yet only 16.4% of eligible women are screened for CC.5 this is far below the world health organization's (who) target if 70% screening coverage; prioritizing access among women living with HIV given their higher risk of developing CC. Women who are screened and referred for treatment onsite (precancerous lesions) or off-site (cancerous lesions) experience high rates of loss to follow up (30-60%) during treatment. Many system and patient level barriers continue to exist resulting in significant morbidity and mortality that could be prevented. Innovative and feasible ehealth strategies have improved clinical outcomes and patient retention in low resource settings and could be key to reaching global targets for CC screening and treatment coverage in kenya. To help address system level barriers to CC screening, treatment, and follow-up, our team worked with end-users (providers and patients) to develop the cancer tracking system (catsystem), a web-based, algorithm generated tool to promote guideline adherent CC screening and retention through treatment. We piloted the catsystem in a kenyan hospital and found that rates of onsite treatment for precancerous lesions and referral for treatment for women with positive screens were higher (2.5 to 5-fold improvement) during the pilot compared to service provision six months prior. The goal of this project is to rigorously evaluate the efficacy, implementation, and cost-effectiveness of the catsystem to improve rates of screening, treatment, referral, and follow-up care in a matched, cluster randomized controlled trial in 10 kenyan government hospitals (5 intervention, 5 standard of care (SOC)). Specific aims (SA) of the study are to (1) implement and evaluate the efficacy of catsystem to improve guideline adherent CC screening, treatment, referral and follow up, (2) assess feasibility and acceptability of implementation of catsystem in government run facilities using a human centered design approach, and (3) calculate the costs and cost-effectiveness of the catsystem to increase quality adjusted life years gained. CC cancer deaths can be prevented with early detection and treatment. This study will evaluate the public health impact of the catsystem in improving CC screening, treatment, referral, follow-up, and the feasibility of scale up to other low resource settings.

Transactions

Action Obligated Date
Amendment $239,951
Amendment $271,496
Amendment $258,246
Amendment $256,403
Amendment $527,705
Amendment $583,607
Original award $583,607

Subawards

Subrecipient Amount Awarded
Global Health Innovations GHI will be responsible for organizing stakeholders for study trainings and disseminations to manage the CATSystem roll out. May Maloba will be the key point of… $498,197
Global Health Innovations Maloba will be responsible for organizing stakeholders for study trainings and disseminations. She will be the key point of contact for study site coordinators,… $226,815
San Diego State University Foundation Dr. Goggin will assist in qualitative analyses from focus groups in Aim 2 and 3 to determine feasibility of implementation in government run facilities from the… $62,190
Regents Of The University Of Michigan Dr. Hutton will be involved in the project: 1. Developing an economic model of the new intervention protocol. 2. Designing and supervising economic data… $41,350
Dartnet Institute Dr. Mabachi is a Health Communications and community based participatory research specialist. She will have overall responsibility for the scientific… $215,178

Quick answers

Who received award R01CA278617?

R01CA278617 was awarded to University Of Kansas Medical Center Research Institute, Inc. by National Cancer Institute (National Institutes of Health) on August 15, 2023.

How much is award R01CA278617 worth?

$2,721,015 has been obligated on R01CA278617.

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