Incorporating residential histories into assessment of cancer risk in a predominantly low-income and racially diverse population
Ended Project Grant Awarded Last action
- Award ID
- R01CA276266
- Recipient
-
Vanderbilt University Medical Center UEI GYLUH9UXHDX5
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $3,401,051
Award facts
- Assistance listing
- 93.393 Cancer Cause and Prevention Research
- Completion date
- Place of performance
- Nashville, TN 37203, USA
Award details come from USAspending.gov.
Description
- Abstract
- There is growing recognition that area-level biological and physical exposures associated with residential location across the life-course must be considered for more precise cancer risk and outcomes. Yet many cohort studies lack comprehensive residential history information or limit analyses to the residence at enrollment or cancer diagnosis, a critical limitation in assessment of exposure causation potentially leading to misclassification or biased associations. Residential histories derived from commercial vendors offer an exciting opportunity to integrate the neighborhood environment into cancer research. Little research has been conducted incorporating life-course residential history information into cohort studies, particularly among historically marginalized populations living in persistent poverty regions such as in the southeast. Populations living in the southeast have the highest cancer risk and some of the poorest health outcomes among all U.S. Populations. To address gaps in knowledge of how best to integrate geospatial data via life-course residential histories into cancer research cohort studies, we propose to evaluate residential histories in a well-resourced and large-scale observational prospective cohort of underrepresented adults, with the following specific aims: 1) collect and describe self-reported adult life-course residential histories from a historically marginalized population, 2) develop algorithms to reconstruct temporal residential histories for historically marginalized individuals, and 3) evaluate residential mobility and spatiotemporal changes in area-level life-course exposures and cancer disparities. We hypothesize concordance of residential history between vendor and self-report varies by population group and incorporating residential mobility improves exposure assessment and reduces bias in cancer research. We propose to construct residential histories, link residential histories to geospatial exposures, and test associations between geospatial exposures across the life-course and cancer disparities. We will focus on the four most common cancers (breast, lung, colorectal, prostate) in over 84,000 participants recruited across 12 southern states. Our design focuses on robust methods to identify factors predictive of residential history patterns among historically marginalized populations, including those living in persistent poverty regions, and novel translation of residential history information into an interpretable context. Our project then examines neighborhoods which can influence cancer risk over space and time. Our project fosters innovative collaborations among a multidisciplinary team with scientific expertise in cancer disparities, cancer epidemiology, survey design, geospatial analyses, small area estimation, and biostatistics. Findings from our multidisciplinary approach will have sustained impact since IT will reveal pathways for improved precision to incorporate area-level exposures across the life-course and motivate strategies to address disparities.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $1,126,520 | |
| Amendment | $1,126,520 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $546,132 | |
| Original award | $601,879 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| The Medical College Of Wisconsin, Inc. | $73,098 | |
| Regents Of The University Of Minnesota | $131,323 | |
| The Medical College Of Wisconsin, Inc. | $73,097 | |
| Regents Of The University Of Minnesota | $150,666 | |
| The Medical College Of Wisconsin, Inc. | $50,366 | |
| Regents Of The University Of Minnesota | $126,955 | |
| The Medical College Of Wisconsin, Inc. | $68,993 |
Quick answers
Who received award R01CA276266?
R01CA276266 was awarded to Vanderbilt University Medical Center by National Cancer Institute (National Institutes of Health) on September 21, 2023.
How much is award R01CA276266 worth?
$3,401,051 has been obligated on R01CA276266.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award