An integrated community-clinic model of optimized implementation strategies to increase early detection of breast and cervical cancers in kenya

Active Project Grant Awarded Last action

Award ID
R01CA269472
Recipient
Awarding agency
Obligated
$10,006,959

Award facts

Assistance listing
93.393 Cancer Cause and Prevention Research
Completion date 75% complete
Place of performance
Marblehead, MA 01945, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Kenya has a high incidence of breast and cervical cancers, and most women are diagnosed with late- stage disease. Implementing effective programs to screen and detect these cancers at an early stage could substantially decrease the high mortality. Kenya has been increasing access to cancer screening, but less than one-sixth of eligible women have ever received breast and cervical cancer screening. The goal of the study is to assess the effectiveness and cost-effectiveness of multicomponent strategies to increase the uptake of breast and cervical cancer screeening. A key GAP that perpetuates the low screening rates in kenya is the lack of community-clinic linkages. There is evidence that women are often unaware of the screening services offered in facilities, and, even among those who are aware, there is lack of motivation, anticipated or perceived stigma, and reduced self-efficacy to undergo screening. We will conduct a pragmatic cluster randomized trial to evaluate the screening outcomes, including screening uptake, diagnostic test completion, and treatment initiation and implementation outcomes to support scale- up. We will test two multicomponent packages of strategies: (1) cancer community-clinic linkage (C3LINK) core: community health volunteer (CHV)-delivered group education for women and family members to increase screening uptake in the community setting and practice facilitation to improve the screening process and develop team-based care with CHV participation in the clinic setting; (2) C3LINK plus: C3LINK core strategies along with a sequential series of individual strategies that increase in intensity at 3-month intervals; women who remain unscreened will first receive one-on-one education; second, motivational interviewing; and, finally, navigation to address specific barriers. We will implement the study across 27 communities in kenya to address the following three specific aims: aim 1: conduct a cluster randomized trial to assess short-term (intervention implementation phase) and longer-term impacts (maintenance phase) of the two packages of multicomponent strategies on breast and cervical cancer screening outcomes along the continuum of care compared to enhanced standard of care (communities receiving a messaging campaign only); aim 2: use a mixed-methods approach to assess and compare multilevel implementation outcomes of the package of strategies focusing on acceptability, feasibility, appropriateness, fidelity, and sustainability; aim 3: perform cost-effectiveness and return-on- investment analysis to support scale-up of an effective package of implementation strategies across kenya and other sub-saharan african countries. The kenyan ministry of health can use the findings from this study to design optimal approaches and plan investments in screening infrastructure to scale up implementation of guideline recommendations. The lessons learned can be applied to other sub-saharan african settings.

Transactions

Action Obligated Date
Amendment $0
Amendment $23,207
Amendment $23,207
Amendment $566,332
Amendment $566,332
Amendment $23,207
Amendment $23,207
Amendment $35,462
Amendment $35,462
Amendment $528,023
Amendment $528,023
Amendment $29,541
Amendment $29,541
Amendment $92,485
Amendment -$92,485
Amendment -$92,485
Amendment $92,485
Amendment $92,485
Amendment -$92,485
Amendment $531,702
Amendment $531,702
Amendment $531,702
Amendment $531,702
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $463,808
Amendment $463,808
Amendment $463,808
Amendment $463,808
Amendment -$458,930
Amendment -$458,930
Amendment $463,808
Amendment -$458,930
Amendment -$458,930
Amendment -$458,930
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Show 40 more

Latest 50 listed here. See the rest on GovTribe.

Subawards

Subrecipient Amount Awarded
Research Triangle Institute To assist with data collection, conduct analysis and support modeling work $316,402
Kenya Medical Research Institute To support cervical cancer screening in Kenya $151,708

Quick answers

Who received award R01CA269472?

R01CA269472 was awarded to Implenomics Llcs by National Cancer Institute (National Institutes of Health) on February 1, 2023.

How much is award R01CA269472 worth?

$10,006,959 has been obligated on R01CA269472.

On GovTribe

See this award's full record

  • Every transaction and subaward
  • The recipient's other awards and teaming partners
  • Similar grant awards
  • Ask GovTribe AI about this award
Try for free Login