Project Grant R01AT013366
- The National Institutes of Health National Center for Complementary and Integrative Health awarded The Leland Stanford Junior University $787,346 on April 13, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to restore key functions to the industrialized gut microbiome. The project characterizes microbial strains capable of fermenting microbiota-accessible carbohydrates (MACs) into short-chain fatty acids (SCFAs)—acetate, propionate, and...
- The National Institutes of Health National Center for Complementary and Integrative Health awarded The University of Chicago $1,206,896 on August 12, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) for Project Grant R01AT013753. The award funds research investigating exclusive metabolic niches as a strategy for precision microbiome manipulation. The work encompasses three aims: investigating the ecological function of exclusive metabolic...
- The National Center for Complementary and Integrative Health, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $128,695 on July 20, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The project investigates how gut-derived microbial metabolites regulate host energy metabolism, with focus on the mechanistic basis for cross-kingdom metabolic interactions relevant to...
- The National Center for Complementary and Integrative Health, under the Department of Health and Human Services National Institutes of Health, awarded The Trustees of Columbia University in the City of New York $167,400 on April 10, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The project characterizes neural circuits regulating the adrenal medulla during stress responses. Specifically, the work maps connections between the motor cortex and...
- The National Center for Complementary and Integrative Health awarded University of California, Los Angeles $697,641 on August 15, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to conduct a randomized, double-blind, placebo-controlled mechanistic clinical study examining probiotic regulation of gut-microbiome-brain interactions in obesity and eating behaviors. The study treats 250 participants (200 with obesity, 50 controls without obesity)...
- The National Center for Complementary and Integrative Health awarded $831,984 to Scripps Research Institute on April 17, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to investigate the neural mechanisms by which the interoceptive system co-regulates emotional and autonomic responses. The research addresses the coupling between emotion and autonomic control—phenomena such as anxiety elevating blood pressure, stress inducing sighing, and...
- The National Center for Complementary and Integrative Health awarded the University of California, San Diego $428,855 on April 1, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to develop computational and experimental approaches for identifying donor microbiota communities capable of stably engrafting in fecal microbiota transplantation (FMT) therapies. The research addresses a critical gap in predicting FMT outcomes by hypothesizing that...
- The National Center for Complementary and Integrative Health, part of the Department of Health and Human Services National Institutes of Health, awarded $439,500 to the University of California, San Diego on April 1, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award funds development of structural biology tools to enable high-resolution cryo-EM elucidation of type I polyketide synthases isolated directly from natural producer...
- The National Center for Complementary and Integrative Health awarded Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, $592,063 on July 20, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) for mechanistic research into probiotic interactions with host diet, digestive metabolism, and the microbial system. The award funds investigation of two metabolic pathways by which Lactobacillus rhamnosus GG regulates gut...
- The National Center for Complementary and Integrative Health, a component of the Department of Health and Human Services National Institutes of Health, awarded Regents of the University of Michigan $546,000 on August 15, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) for Project Grant R61AT013720. The award funds a two-phase investigation into precision probiotics engineered to support lactate metabolism and organ recovery in hospitalized...
The National Center for Complementary and Integrative Health, part of the Department of Health and Human Services National Institutes of Health, awarded $413,972 to Oklahoma State University Center for Health Sciences on August 12, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award funds investigation of how early life stress triggers imbalances in gut bacterial genera, particularly Roseburia, and influences brain responses through modifications in astrocyte-neuron plasticity. The research examines whether favorable interventions can reverse stress-induced behavioral dysregulation by engaging distinct gut commensals and brain pathways. The project comprises two aims. Aim 1 uses animal models to determine how Roseburia inoculation modifies emotional and cognitive behaviors in stress-exposed versus standard-reared mice, employs viral tools to visualize neuronal and astrocytic mitochondrial function in vivo, and manipulates epithelial signaling to test causal links between intestinal stress responses, microbial composition, and brain plasticity. Aim 2 examines how favorable environmental factors such as enrichment and cross-fostering reshape the gut-brain axis following early life stress, profiling gut microbiome composition, intestinal barrier integrity, and metabolite production through metagenomic and metabolomic analyses, while parallel brain-wide proteogenomic and single-cell sequencing identify molecular pathways for stress resilience. Performance occurs in Tulsa, Oklahoma. The project period extends through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $414.0k | 8/13/26 |