This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under CFDA Program 93.213 - Research and Training in Complementary and Integrative Health, provides $682,570.00 to Georgia State University Research Foundation Inc. to conduct research on the impact of chronic social stress on mechanosensation of the heart and gut. The research aims to investigate how chronic social defeat stress in mice affects the activity of neurons in the nodose ganglia that express oxytocin receptors, which serve as mechanoreceptors relaying information about cardiovascular and gastrointestinal stretch to the brain. The project will use intravital imaging, genetically engineered mouse models, and chemogenetic stimulation to determine if blunted mechanosensation contributes to the development of cardiometabolic and affective disorders associated with social adversity. The award period runs from January 1, 2025 through November 30, 2029.
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