A remotely delivered TAI CHI/qigong intervention for older people living with HIV: a randomized clinical trial

Active Project Grant Awarded Last action

Award ID
R01AT012590
Recipient
Awarding agency
Obligated
$2,366,702

Award facts

Completion date 47% complete
Place of performance
Miami, FL 33199, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Half of those living with HIV in the united states are over 50 years of age. As people living with HIV (PWH) live longer with the disease, the tradeoff is that they live with multiple comorbidities. One of the more common comorbidities is depression. There is a need to find innovative and accessible nonpharmacological interventions that can help older people living with HIV/aids to manage depressive symptoms that may also affect their treatment outcomes. TAI CHI/qigong (TCQ) is a series of slow, low-impact meditative movements that integrate breath work, meditation, and stances; and may improve depressive symptoms. We propose testing the efficacy of a remotely delivered standardized TCQ intervention that has shown to be acceptable and feasible with a population of older people living with HIV/aids. Thus, this study proposes three aims: (I) to determine whether a remotely delivered TCQ intervention is directly efficacious in improving depressive symptoms compared to a health education control group among older PWH (50 years of age or older); (II) to determine whether a remotely delivered TCQ intervention indirectly improves depressive symptoms via biological, psychological, and behavioral mechanisms compared to a health education control group among older PWH and (III) to determine whether the direct and indirect associations between a TCQ intervention and depressive symptoms is moderated by gender among older PWH. Participants (N=326) will be recruited using social media sites (e.g., webmd, google, facebook) throughout the united states, and from at least two contact registries of older PWH. For the registries, research staff will contact participants via phone. All assessments will be conducted via zoom videoconferencing or phone. Participants will be randomized to 1 of 2 conditions: the TCQ intervention, or a health education control group condition. Both the TCQ and the health education control condition will be delivered via zoom to participants in the form of live, synchronous classes. We will assess the efficacy of TCQ by looking at instruments that measure depression; and potential mechanisms such as sleep, fatigue, emotional regulation, and heart variability at baseline, 3-month, and 9-month post-intervention. Blood will also be collected via quest diagnostics at baseline and at 9-month to collect viral load and an inflammatory marker (C-reactive protein). Data will be described using descriptive techniques. Efficacy of the TCQ treatment will be evaluated using a random effects analysis of covariance (ANCOVA) model. We will follow the baron & kenny's method for mediation analysis to assess if the effect of TCQ intervention on depressive symptoms is mediated by biological (heart variability, using HF power values expected to increase), psychological (emotional regulation, anxiety, stress), and behavioral (fatigue, sleep) variables.

Transactions

Action Obligated Date
Amendment $470,307
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Amendment $48,413
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Amendment $435,711
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Original award $492,436
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Subawards

Subrecipient Amount Awarded
New College Of Florida Project summary: TCQ, a series of slow, low-impact meditative movements that integrates breath work, meditation, and stances shows growing evidence for… $39,546
Arizona State University Scope: Participants will be recruited throughout the United States completely online. We will use top-quality instructors from the Tai Chi Easy Practice… $77,873

Quick answers

Who received award R01AT012590?

R01AT012590 was awarded to Florida International University by National Center for Complementary and Integrative Health (National Institutes of Health) on July 8, 2024.

How much is award R01AT012590 worth?

$2,366,702 has been obligated on R01AT012590.

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