Optimizing response to chronic pain treatments in veterans: identifying key moderators
Active Project Grant Awarded Last action
- Award ID
- R01AT011012
- Recipient
-
University Of Washington UEI HD1WMN6945W6
- Awarding agency
-
National Center for Complementary and Integrative Health
National Institutes of Health, Department of Health and Human Services
- Obligated
- $11,060,747
Award facts
- Assistance listing
- 93.213 Research and Training in Complementary and Integrative Health
- Completion date 88% complete
- Originally
- Funding
-
- $10,747,603.00 Federal
- $313,144.00 Non-federal
- Place of performance
- Seattle, WA 98195, USA
Award details come from USAspending.gov.
Description
- Abstract
- Chronic pain is a prevalent, disabling problem affecting as many as 50% of men and 75% of women veterans. The psychosocial pain treatment with the most empirical support is cognitive behavior therapy (CBT). However, not everyone benefits from CBT. Prior research has shown that two complementary and integrative health (CIH) interventions, mindfulness-based cognitive therapy (mbct) and hypnotic cognitive therapy (HYP-CT), are beneficial and offer alternatives to CBT and have similar efficacy. As with CBT, individual response to these treatments also varies considerably. Our preliminary data suggests the variability in treatment outcome may be due to important baseline patient differences. This suggests the possibility that patients can be effectively "matched" to the treatments they are most likely to benefit from, based on information that can be obtained before treatment starts. Research is needed to develop patient-treatment matching algorithms that could match a given individual to the evidence-based treatment most likely to be beneficial given their unique individual profile. The overall aim of the proposed study is to address this need by identifying patient factors that determine who benefits most from two CIH treatments and the current gold standard non-pharmacological treatment (CBT), relative to usual care. This aim will be addressed using a clinical trial in which participants will be randomized to one of the four treatment conditions. We will test hypotheses - developed from both theory and prior pilot research - that pre-treatment brain activity patterns, hypnotizability, catastrophizing, and mindfulness moderate pre- to post-treatment improvements in pain intensity associated with group-delivered CBT, mbct, and HYP-CT, relative to usual care, in veterans with chronic pain. The findings will provide the foundation for building an algorithm to support personalized care, whereby veterans can be offered the treatment that will be most beneficial for them. This study will also help develop knowledge about potentially powerful alternatives to pharmacological analgesic approaches. Finally, the study findings will be useful to health care providers and their patients to facilitate shared decision-making.
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Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Seattle Institute For Biomedical And Clinical Research | -$5,506 | |
| Seattle Institute For Biomedical And Clinical Research | $49,222 | |
| Seattle Institute For Biomedical And Clinical Research | $17,912 | |
| Seattle Institute For Biomedical And Clinical Research | $121,507 | |
| Seattle Institute For Biomedical And Clinical Research | $11,211 |
Quick answers
Who received award R01AT011012?
R01AT011012 was awarded to University Of Washington by National Center for Complementary and Integrative Health (National Institutes of Health) on September 15, 2021.
How much is award R01AT011012 worth?
$11,060,747 has been obligated on R01AT011012: $10,747,603 in federal funding and $313,144 in non-federal funding.
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