Project Grant R01AR086176
- This federal Project Grant award of $570,174 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports the development and evaluation of a zonal-specific mineralized scaffold optimal for osteochondral (OC) tissue regeneration. The research aims to mimic the hierarchical microstructure and composition of native OC tissue, which consists of articular cartilage and subchondral...
- This federal Project Grant award of $685,866.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The goal of this 5-year project is to leverage context-specific expression quantitative trait loci (eQTLs) to identify potential causal genes underlying genome-wide association study (GWAS) findings related to bone mineral density (BMD) and...
- This Project Grant award of $170,931 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support a 5-year research and career development program for Dr. Diana Athonvarangkul at Yale University. The research aims to elucidate the mechanisms regulating osteocytic osteolysis, a process by which the most abundant bone cell type, the osteocyte, remodels bone. Specifically,...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $688,634.00 in funding to The Hospital For Special Surgery Fund, Inc. (dba HSS Foundation) from December 1, 2024 to November 30, 2029. The award supports research to investigate the mechanisms by which the constitutive type-I interferon (IFN-I) response suppresses osteoblastogenesis and bone formation, especially in the context of inflammatory conditions like rheumatoid...
- This $465,663 Project Grant was awarded on May 6, 2025 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports research to optimize the bone surface targeting of therapeutic antibodies for the treatment of osteoporosis, a common bone disease affecting 10 million U.S. adults. The project aims to increase the local concentration and efficacy of osteoporosis...
- This $219,609 project grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is aimed at developing a method to assess mechanical failure of bone matrix using in vitro cell culture. The primary goal is to overcome the current challenge of requiring whole mouse bone specimens to detect changes in bone matrix mechanical properties, by using micropillars generated from...
- This federal Project Grant award of $646,506 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting the development of dual-action nanoparticle-loaded microparticles for the treatment of osteoarthritis (OA). The research aims to create innovative nanoparticle-based therapeutics that can stimulate the anabolic activity of chondroprogenitors to enhance cartilage...
- This $159,594 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to identify new therapeutic targets for osteogenesis imperfecta (OI), a rare genetic bone disorder. The award recipient, the Research Foundation of the City University of New York (RFCUNY), will investigate the intracellular signaling and extracellular matrix mechanisms...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $267,423 to The Hospital For Special Surgery Fund, Inc. (doing business as HSS Foundation) to develop a biomarker using circulating cell-free tumor DNA (ctDNA) to assess the safety of immunosuppressive drugs used to treat inflammatory arthritis caused by immune checkpoint inhibitor...
- This Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research Program (CFDA 93.846), provides $412,756 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on the mechanisms regulating bone healing and angiogenesis in osteonecrosis. The research aims to fully characterize the process of stem cell differentiation and revascularization in...
The federal Project Grant award of $445,217 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into the regulatory mechanisms of osteoclasts. Osteoclasts are cells primarily responsible for bone resorption, and their dysregulation is key to the pathophysiology of bone diseases such as osteoporosis, rheumatoid arthritis, and lytic bone metastasis. The research aims to determine the mechanisms underlying the regulation of circulating osteoclast precursor cells (COCPs), which play a critical role in the management of osteoclasts. The project will be carried out by the Hospital for Special Surgery Fund, Inc. (doing business as HSS Foundation), a non-profit research institution focused on advancing medical understanding and treatment of complex musculoskeletal conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $445.2k | 8/13/25 |