Project Grant R01AI205724
- The National Institute of Allergy and Infectious Diseases awarded $297,000 to Texas Biomedical Research Institute on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund research on targeting super-enhancers to regulate HIV transcription and latency. The project, identified as R21AI203697, will define molecular mechanisms by which super-enhancer-associated long non-coding RNAs (SE-lncRNAs) regulate HIV transcription and maintain viral latency in...
- The National Institute of Allergy and Infectious Diseases awarded The University of Texas Southwestern Medical Center $249,000 on July 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of convergent RNA polymerase II transcription in HIV-1 latency and reactivation. The research aims to define how convergent POL II transcription—specifically antisense and downstream forms originating from the 5'-LTR—regulates sense HIV-1 transcription...
- The National Institute of Allergy and Infectious Diseases awarded the University of Texas Medical Branch at Galveston $294,150 on August 1, 2026, for research on defective pro-viruses and viral proteins in neuroHIV and HIV cure strategies under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research employs correlative microscopy (live-cell, confocal, and electron microscopy), mass spectrometry imaging, and spatial proteomic and mRNA analysis to detect, quantify, and...
- The National Institute of Allergy and Infectious Diseases awarded The University of Texas Southwestern Medical Center $828,340 on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate HIV-1 transcription reactivation mechanisms in latent reservoir cells. The research explores the role of transcription factors and Tat protein in initiating and sustaining HIV-1 transcription reactivation, using genetic and genomic approaches to examine HIV-1...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $2,461,651 to the University of Texas Health Science Center at Houston under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 18, 2025, for a project extending through July 31, 2029. The project investigates estrogen's impact on immunoglobulin G (IgG) glycomic modulation of immunity and inflammation in people with human immunodeficiency virus (HIV) on antiretroviral...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $874,531 on May 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to model dynamic CD8+ T cell–virus interactions in post-treatment control of HIV. The project comprehensively defines mechanistic features of CD8+ T cell responses that most strongly relate to control of HIV after stopping antiretroviral therapy. Research will examine...
- The National Institute of Allergy and Infectious Diseases awarded Texas Biomedical Research Institute $927,025 on May 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to evaluate IL-21-IGFC therapy for enhancing pulmonary immune reconstitution and limiting viral persistence in co-infected macaques. The research addresses incomplete immune reconstitution in individuals co-infected with HIV and tuberculosis despite antiretroviral therapy, using an established...
- The National Institute of Environmental Health Sciences, part of the National Institutes of Health, awarded the University of Texas Health Science Center at Houston $200,268 on September 1, 2026, under the Medical Library Assistance program (CFDA 93.879) for Project Grant R21LM015664. The recipient will develop DEEPHIV-AOU, a multi-modal deep learning framework designed to improve HIV prevention through personalized risk assessment and intervention planning. The framework integrates four...
- The National Institute of Allergy and Infectious Diseases awarded Scripps Research Institute $253,256 on June 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to establish HIV infection, treatment, and engineered B cell memory responses in the THX mouse model through May 31, 2028. The project develops a preclinical platform for engineered B cell therapies aimed at creating a functional HIV cure. Scripps will determine whether immunoglobulin heavy chain...
- The National Institute of Allergy and Infectious Diseases awarded the University of Miami $653,743 on August 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and test implementation strategies for integrating the JUNTOS referral network into HIV self-testing programs in South Florida. The project aims to improve clinical linkage and engagement for individuals engaging in HIV self-testing by deploying JUNTOS, an app and website that centralizes...
The National Institute of Allergy and Infectious Diseases awarded The University of Texas Health Science Center at San Antonio $855,899 on August 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to implement and test PL4Y (PositiveLinks for Youth), a mobile health intervention designed to improve care engagement and virologic suppression among young adults with HIV ages 18–29 in Texas. PL4Y is a multimodal intervention delivering daily adherence and mood assessment, appointment reminders, secure messaging, and an anonymous asynchronous virtual support group via smartphone application. The project will operate across a six-clinic network in Austin, Dallas, Houston, and San Antonio—four of the five Ending the HIV Epidemic priority jurisdictions in Texas. A pilot randomized controlled trial demonstrated that PL4Y increased virologic suppression from 44 percent in the control group to 80 percent in the intervention group and showed high acceptability and feasibility among youth living with HIV in South Texas. Work is performed in San Antonio, Texas, with a period of performance through July 31, 2031. The award is classified as a Project Grant. The research team includes clinician researchers, implementation scientists, and behavioral intervention experts, alongside a youth advisory board providing input throughout implementation. The project builds on prior NIH-supported development work and aims to establish whether PL4Y can improve rates of virologic suppression and transform HIV management outcomes for young adults in the South, where molecular clusters of rapid transmission indicate gaps in care engagement and treatment adherence.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $855.9k | 8/5/26 |