Project Grant R01AI201788
- The National Institute of Allergy and Infectious Diseases awarded Northeastern University $100,228 on December 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of G-quadruplex DNA structures in the antigenic variation mechanism of Borrelia burgdorferi, the causative agent of Lyme disease. The research addresses the molecular mechanism by which B. burgdorferi evades host adaptive immune defenses through antigenic variation—reshaping outer...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Tufts University School of Medicine a $165,000 project grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 1, 2025, with a completion date of June 30, 2027. This award funds the development of an improved transposon mutagenesis system for comprehensive genetic analysis of Borrelia burgdorferi, the causative agent of Lyme disease. The primary deliverables...
- The National Institute of Allergy and Infectious Diseases awarded the University of Pittsburgh $715,313 on June 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate Borrelia burgdorferi genotypic diversity, pathogenesis, and host cellular responses in Lyme disease. The award funds research on Borrelia burgdorferi outer surface protein C (OspC) genotypes and their association with disease severity and progression, including Lyme neuroborreliosis (LNB)....
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Tufts College, doing business as Tufts University School of Medicine, $862,348 on August 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define the mechanisms targeting a Borrelia burgdorferi protein CspZ to prevent Lyme disease infection. The project addresses mechanisms by which B. burgdorferi evades complement-mediated immune killing. The recipient has generated a CspZ mutant...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $417,845 to the University of Nebraska Medical Center under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year project period from August 1, 2025, through July 31, 2027. The award supports the development and adaptation of an innovative in vitro organotypic human skin model designed to enable tick feeding and study the transmission and colonization of Borrelia...
- The Virginia Commonwealth University was awarded a $746,009 Project Grant from the Department of Health and Human Services National Institutes of Health National Institute of Allergy and Infectious Diseases. The grant falls under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research examining the cyclic-di-GMP signaling pathway and its role in the enzootic cycle of Lyme disease from November 18, 2022 through October 31, 2027. Specifically, the grant will fund...
- Federal Project Grant Award Summary The University of Connecticut Health Center received a $457,875 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 1, 2025, through June 30, 2027. The award supports biomedical research investigating the role of the RpoS (sigma factor) regulatory protein in the persistence of Borrelia burgdorferi, the spirochete bacterium that causes...
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Tufts College (doing business as Tufts University School of Medicine) $859,278 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to accelerate discovery of narrow-spectrum antibiotics targeting Borrelia burgdorferi, the causative agent of Lyme disease. Narrow-spectrum agents that affect only the target bacterium avoid resistance propagation in off-target bacteria, microbiome...
- The National Institute of Allergy and Infectious Diseases awarded The University of Kentucky Research Foundation $420,063 on February 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify and functionally characterize bacterial and phage proteins that control BB-1 bacteriophage production in Lyme disease spirochetes. The funded research targets the molecular switches governing the transition of BB-1 bacteriophages from dormant plasmid replication to lytic...
- The National Institute of Allergy and Infectious Diseases awarded the University of Connecticut Health Center $457,875 on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate independent gene regulation by the Borrelia burgdorferi FUR ortholog BosR. The research examines how BosR, the sole member of the ferric uptake regulator family in Borrelia burgdorferi (the Lyme disease spirochete), regulates genes outside the well-studied rpoN/rpoS...
The National Institute of Allergy and Infectious Diseases awarded the University of Toledo $768,796 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify immunoprotective antigens for preventing Lyme disease caused by Borrelia burgdorferi. The research will evaluate attenuated bacterial mutants as vaccine candidates, building on the recipient's prior identification of a BB strain lacking a chemotaxis-related gene that is rapidly cleared from infected hosts without causing clinical disease while generating protective B and T cell responses. The award funds a five-year project through August 31, 2031, with place of performance at the University of Toledo Health Science Campus in Toledo, Ohio. This is a Project Grant, classified as assistance funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $768.8k | 8/28/26 |