Project Grant R01AI198555
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $807,330 on August 12, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Massachusetts General Hospital to develop potent antibody therapeutics against malaria parasites. The research, scheduled for completion by July 31, 2030, focuses on identifying and characterizing highly effective human monoclonal antibodies targeting the circumsporozoite...
- Federal Grant Award Summary Seattle Children's Research Institute received a $516,175 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on June 23, 2025, with a completion date of May 31, 2027. The award funds research evaluating the impact of pre-existing humoral immunity on hepatocyte death in the context of malaria infection and vaccine efficacy. The research addresses a...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Indiana University Indianapolis a Project Grant of $790,946 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 10, 2026, with a completion date of January 31, 2031. This research award supports investigation into the dysregulation of humoral immunity following Plasmodium infection, specifically examining why malaria parasites fail to induce long-lasting antibody...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Medical College of Wisconsin, Inc. a Project Grant totaling $157,884 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period of December 26, 2025 through June 30, 2029. This research grant supports investigator-initiated biomedical research aimed at advancing understanding of infectious disease mechanisms and improving vector control strategies against malaria...
- Federal Grant Award Summary The University of South Florida received a $375,000 Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 10, 2025, with performance through May 31, 2030. This award supports biomedical research investigating the functions of membrane-less ribonucleoprotein (mRNP) granules in RNA metabolism within Plasmodium falciparum, the human malaria parasite. The research...
- Federal Grant Award Summary The University of South Florida received a $412,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 3, 2025 through June 30, 2027. The award supports research focused on evaluating immunodominant fragments of Plasmodium falciparum Glutamic Acid Rich Protein (PfGARP) for malaria vaccine development. The project builds on prior laboratory...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $451,000 to the University of California, San Francisco under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 15, 2025, with completion scheduled for July 31, 2027. This Project Grant supports the development and application of high-resolution phage immunoprecipitation sequencing (PhIP-Seq) arrays designed to comprehensively evaluate antibody responses to...
- Federal Project Grant Award Summary The University of South Florida received a Project Grant award of $203,060 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 1, 2026 through March 31, 2028. This research initiative focuses on investigating the ecology of Plasmodium malariae transmission in Cameroon, specifically addressing the patchy distribution and seasonal variations of this...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Washington University a Project Grant totaling $545,236 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct investigative research on heme homeostasis mechanisms in the malaria parasite Plasmodium falciparum. The award, dated July 16, 2025, with a completion date of January 31, 2027, will deliver fundamental scientific research aimed at identifying and...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of California, San Francisco a Project Grant of $895,740 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period February 2, 2026 through January 31, 2031. This award supports research focused on characterizing CD4 T cells targeting liver and blood stage malaria epitopes to advance malaria vaccine development. The research will identify hundreds...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded Hennepin Healthcare Research Institute a Project Grant of $661,037 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective May 1, 2026, through April 30, 2031. The award supports biomedical research investigating the use of interleukin-15 (IL-15) cytokine-based therapy to enhance T cell and B cell immune responses against Plasmodium parasites that cause malaria. The research project will utilize novel peptide:major histocompatibility complex (MHC) Class II and B cell tetramers in experimental Plasmodium infection and vaccination mouse models to examine how IL-15 therapy promotes the differentiation of T follicular helper (TFH) cells and liver-resident memory T (TRM) cells, ultimately seeking to develop improved vaccine immunogenicity and therapeutic strategies. The project addresses a critical public health need, as malaria remains a significant global burden with approximately 250 million clinical cases and over 600,000 deaths annually. Current malaria vaccines demonstrate limited durability and efficacy in endemic areas, and growing antimalarial drug and insecticide resistance necessitate novel therapeutic approaches. By investigating how IL-15 therapy can enhance the robustness and durability of immune responses to Plasmodium infection and vaccination, this research aims to generate scientific knowledge and therapeutic candidates that could improve vaccine development and clinical outcomes for malaria prevention worldwide.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $661.0k | 5/1/26 |