Project Grant R01AI195492
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Pittsburgh a Project Grant totaling $412,942 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 5, 2026, with a completion date of January 31, 2028. This R21 developmental research grant funds an investigation into how host-derived environmental signals in the gastrointestinal tract regulate hypervirulent Klebsiella pneumoniae (HVKP)...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Washington University a $777,360 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2030. This award funds research titled "Advancing Lymphatic Filariasis Elimination with Parasite Genomic Epidemiology," which will deliver comprehensive genomic analysis and characterization of Wuchereria bancrofti...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $427,625 Project Grant to the University of North Carolina at Chapel Hill under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period July 1, 2025 through June 30, 2027. The grant funds research investigating the role of fimbriae—surface-expressed protein appendages on bacterial cells—in hypervirulent Klebsiella pneumoniae (HVKP) mediated liver abscess formation....
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Washington University a Project Grant totaling $664,076 under the Allergy and Infectious Diseases Research program (CFDA 93.855) beginning April 1, 2026, and concluding March 31, 2031. This research award funds investigator-initiated biomedical research to elucidate the molecular mechanisms by which Staphylococcus aureus alpha-toxin (HLA) impairs antigen-specific T cell responses and...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston University Medical Campus a $176,738 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective September 1, 2025, through August 31, 2030. This award supports a mentoring and capacity-building initiative focused on training junior investigators from the United States and low-income countries (LICs) in patient-oriented research (POR) related to...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $717,003 Project Grant on April 6, 2026, to the University of Wisconsin-Madison under the Allergy and Infectious Diseases Research program (CFDA 93.855) for research on protective messenger ribonucleic acid (mRNA) vaccines against tuberculosis. The project, with a completion date of March 31, 2031, aims to develop and evaluate a novel combination mRNA vaccine (QRNA) that utilizes...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Washington University a Project Grant totaling $596,115 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, with completion targeted for July 31, 2030. This five-year award supports investigator-initiated biomedical research examining the long-term impact of persistent parainfluenza virus infection, specifically focusing on how human...
- Federal Grant Award Summary Seattle Children's Research Institute received a $3.61 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on July 14, 2025, with a completion date of June 30, 2029. This research project investigates hyaluronidase (HylB), a virulence factor produced by Group B Streptococci (GBS), to elucidate mechanisms by which the enzyme suppresses immune...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Washington University a Project Grant of $162,000 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective June 1, 2025, through May 31, 2027. This award supports investigator-initiated biomedical research focused on characterizing the mechanisms by which plasmacytoid dendritic cells (PDCs) contribute to Mycobacterium tuberculosis (MTB) susceptibility. The...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Washington University a Project Grant totaling $715,894 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 8, 2025, for a five-year research initiative extending through July 31, 2030. This award funds fundamental biomedical research investigating the influence of microbial metabolites on mitosome function in Cryptosporidium parvum, a parasitic pathogen...
Funding Agency and Program: National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855) Award Details and Project Scope:
The Washington University received a Project Grant award of $726,966 effective April 1, 2026, through March 31, 2031, to advance the development of maternal vaccines targeting Klebsiella pneumoniae (KP) neonatal sepsis prevention. The multi-investigator project will deliver fundamental research products through preclinical evaluation of bioconjugate vaccine candidates targeting KP's polysaccharide capsule (K-antigen) and O-antigen using an established murine model of KP neonatal sepsis. Deliverables include characterization of immune responses to maternal vaccination through enzyme-linked immunosorbent assays (ELISAs) quantifying immunoglobulin G (IgG) subtypes in dams and pups, functional assays measuring serum bactericidal and opsonophagocytic killing activity, and comparative efficacy data from matched K and O vaccine variants in protecting neonatal pups from KP bacteremia challenge. The research leverages collaboration with external vaccine development partners and combines expertise in bacteriology, humoral immunity, murine modeling, gnotobiotics, and microbiome analyses to generate scientific evidence supporting the eventual development of a human maternal vaccine addressing an urgent global antimicrobial resistance threat.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $727.0k | 4/1/26 |