This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $142,932 to The Trustees of Columbia University in the City of New York to investigate the potential of wastewater surveillance data to improve SARS-CoV-2 dynamical modeling and forecasting. The primary objectives are to leverage a dataset from the New York State wastewater surveillance network to evaluate how incorporating wastewater data...
This Project Grant award of $537,861 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to extend statistical methods for analyzing infectious disease transmission dynamics. The key objectives are to: Develop efficient computational methods to incorporate pathogen genetic sequences into parameter estimation for pairwise survival analysis models, which can reduce bias and variance in...
This Project Grant award from the National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (CFDA 47.049) provides $249,313 to Lawrence Technological University to enhance dynamic population-level epidemiological models by incorporating wastewater surveillance data. The project aims to improve the estimation of true disease prevalence, enhance forecasting of future COVID-19 cases, and monitor the emergence and evolution of viral variants. Key activities include...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $421,673 to William Marsh Rice University to develop computational tools and laboratory methods for wastewater surveillance of antimicrobial resistant pathogens. The goal is to identify signature genomic regions of antimicrobial resistant pathogens that can be specifically detected in wastewater, enabling more...
This $335,268 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program supports research by the University of Texas at Austin investigating how viruses have evolved mechanisms to evade host immune defenses over millions of years. The research project aims to determine if a specific viral protein, VDUSP11, is conserved across poxviruses that infect a wide range of hosts from insects to vertebrates. The goal is to understand how this...
The University of Texas Southwestern Medical Center was awarded a $454,726 Project Grant by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to investigate cell-intrinsic antiviral immunity mechanisms in bats. The 5-year project aims to study the antiviral properties of the rapidly evolving RNA-binding protein RTP4, which has been shown to inhibit flaviviruses, and to explore the functional diversity of interferon-stimulated genes...
This $549,999 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) will support research at George Washington University to investigate the impacts of bacteria-virus associations on the transmission, persistence, and health effects of enteric viruses in aquatic environments. The key objectives are to: 1) elucidate how bacterial association affects the infectivity, environmental persistence, and disinfection resistance of enteric viruses; 2) investigate the...
This $534,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to develop wastewater surveillance systems for monitoring multidrug-resistant bacteria (MDRB). The key objectives are to: Establish standardized wastewater surveillance strategies to inform clinical infection control responses, using long-read metagenomics and novel bioinformatics to rapidly identify significant changes in...
This Project Grant award of $699,339.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to study the transmission dynamics of dengue and Zika viruses across diverse communities in northwestern coastal Ecuador. The study aims to characterize how changes in environment, social networks, and vector populations influence regional virus transmission patterns. Key activities include...
This $100,000 Project Grant award from the National Science Foundation (NSF) Social, Behavioral, and Economic Sciences (SBE) program (CFDA 47.075) aims to integrate wastewater surveillance and human behavior data to enhance epidemiological modeling and outbreak detection. The principal investigators at Lawrence Technological University will pursue three main objectives: (1) developing an early-warning system using wastewater and digital/social behavior data, (2) creating a...
The University of Texas Health Science Center at Houston received a $568,909 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct a 5-year research project titled "A Wastewater Approach to Viral Transmission, Evolution, and Ecology." The project aims to develop advanced computational models that integrate within-host viral kinetics and between-host transmission dynamics to improve wastewater-based surveillance and prediction of viral spread at the community level. Key objectives include examining evolutionary dynamics of viral variant transitions, analyzing variant community dynamics and ecological interactions across multiple cities, and enhancing the capacity to detect new viral threats early, track their evolution, and understand their ecological interactions. This research is expected to significantly advance the understanding of viral dynamics at the community level and strengthen pandemic preparedness and response capabilities.