Project Grant R01AI192628
- This $1,174,636 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) supports the development of next-generation ELQ compounds for the treatment and prevention of malaria. The research aims to identify novel, rapidly acting anti-malarial drugs to target the blood and liver stages of the Plasmodium falciparum parasite, as well as formulations suitable for long-acting...
- This $451,000 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support the development of a comprehensive, high-resolution array to analyze antibody responses to variant Plasmodium falciparum antigens in populations naturally exposed to malaria. The research team at the University of California, San Francisco will leverage advanced bioinformatic and laboratory methods to create...
- This Project Grant award of $1,553,810 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to evaluate a genomic surveillance approach for monitoring artemisinin resistance in Plasmodium falciparum malaria in Africa. The project aims to identify genetic mutations and altered biological functions associated with artemisinin resistance, which is a critical concern as resistance emerges...
- This federal Project Grant award of $426,938, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to explore the combined use of human anti-RH5 monoclonal antibodies and small molecule inhibitors against asexual Plasmodium falciparum malaria parasites. The research aims to assess the potential for additive, synergistic, or antagonistic effects of these combined interventions in...
- This $122,597 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to analyze the function and antibody-mediated inhibition of the malaria vaccine candidate protein PF3D7_1136200. The project aims to characterize this promising but previously uncharacterized blood-stage malaria antigen, with the goal of advancing development of a highly efficacious malaria vaccine. The...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $375,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of South Florida (USF) to study the functions of messenger ribonucleoprotein (mRNP) granules in regulating mRNA metabolism in the malaria parasite Plasmodium falciparum. The project, running from Jun 10, 2025 to May 31, 2030, aims to identify mRNP markers, characterize their protein and mRNA compositions, and...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $682,200 Project Grant to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM) on August 22, 2025. The grant will support a study to evaluate the impact of early-life malaria exposure on the effectiveness of the RTS,S pre-erythrocytic malaria vaccine in Kenyan infants. The study aims to...
- This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
- This $516,175 Project Grant was awarded on June 23, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant was awarded to Seattle Children's Hospital, doing business as Seattle Children's Research Institute, to evaluate the impact of pre-existing humoral immunity on hepatocyte death in the context of malaria. The research aims to explore how pre-existing immunity to malaria may...
- This federal Project Grant award of $791,864 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify molecular factors controlling chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The research aims to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, with the goal...
This $781,241 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), will support a systems analysis to understand the differential pharmacokinetics and protective efficacy of anti-malarial monoclonal antibodies (mAbs) in field trials. The research aims to leverage prospective clinical data, pharmacokinetic data, and biospecimens from a Phase 2 pediatric trial of the anti-malarial mAb L9LS to conduct unbiased, comprehensive analyses of transcriptomic, metabolomic, and cytokine profiles. This will help determine immune features predictive of L9LS-mediated malaria protection and longer mAb half-life. The project will be conducted by researchers at Indiana University Indianapolis over the award period from Aug 5, 2025 to Jul 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $781.2k | 8/4/25 |