Project Grant R01AI191327
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $123,280 project grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to Instituto De Biologia Molecular Y Celular De Rosario (IBR) in Argentina. The grant aims to investigate the adaptive immune response against Trypanosoma cruzi, the parasite that causes Chagas disease, with the goal of developing effective vaccine candidates. The research will focus on enhancing CD8+ T cell...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $133,746 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Fundacion Instituto De Investigaciones Biotecnologicas, a non-profit research institute in Buenos Aires, Argentina. The grant supports high-throughput analysis of antibody responses against defined epitopes to prioritize diagnostic and prognostic markers for Chagas disease, a parasitic infection endemic to the Americas. The...
- The University of Cincinnati was awarded a $444,688 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant will fund research to characterize cyclic AMP (cAMP) signaling microdomains in the human pathogen Trypanosoma cruzi, which causes Chagas disease - a leading cause of disability and premature death in the Americas. Specifically, the research aims to study the role of cAMP in the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $160,500 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Baylor College of Medicine to develop and validate a highly sensitive serological assay for detecting all geographic variances of Trypanosoma cruzi infection, which causes Chagas disease. This 2-year project aims to address the limitations of current Chagas diagnostic tests and reduce the burden on the healthcare system...
- This $412,581 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to define the roles of specialized mitochondrial DNA polymerases (POLIB and POLID) in the replication and maintenance of the complex kinetoplast DNA network of African trypanosomes. These parasites cause neglected tropical diseases such as human African trypanosomiasis, Chagas disease,...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, will support the development of a panel of antibodies to detect markers of Trypanosoma cruzi infection, the causative agent of Chagas disease. The $449,408 award to Duke University, with a performance period from Jul 1, 2025 to Jun 30, 2027, aims to generate antibodies that can effectively diagnose acute and chronic Chagas...
- This $570,760 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports a multidisciplinary research project to study the structure and function of intraflagellar transport (IFT) in the trypanosomatid parasite Leishmania, which causes several major human diseases. The research aims to elucidate the conserved and parasite-specific features of Leishmania...
- The University of Texas Medical Branch at Galveston (UTMB) received a $440,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), to examine the role of the long non-coding RNA (lncRNA) CHAST in regulating the host immune response to Trypanosoma cruzi (T. cruzi) infection, the causative agent of Chagas disease. The project aims to elucidate how T. cruzi deregulates CHAST...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $239,250 Project Grant to Brown University to investigate life-cycle transitions in trypanosomatid parasites using live-cell imaging. The 2-year project, running from August 2025 to July 2027, will leverage a novel agarose microwell confinement strategy to observe cellular processes like cell division in these important human...
- This Project Grant award, valued at $736,920.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program. The funding supports research conducted by the University of California, Los Angeles (UCLA) to study the structure, assembly, and mechanisms of the trypanosome flagellum, which is essential for the transmission and infection of the Trypanosoma brucei parasite that causes African...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $133,800 to the Fundacion Instituto De Investigaciones Biotecnologicas in Argentina. The funding supports research to fully understand protein trafficking through the contractile vacuole complex (CVC) in the parasite Trypanosoma cruzi, the causative agent of Chagas disease. The research aims to determine if the CVC, which is absent in mammals, could provide a target for new chemotherapies to treat this disease, since the currently available treatments are highly toxic. The project also investigates the distinct distribution of glycosylphosphatidylinositol (GPI)-anchored proteins on the parasite surface and the role of ceramide in GPI anchoring, as this may have implications for the parasite's cell biology, infectivity, and pathogenicity. The award period is from August 11, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $133.8k | 8/11/25 |