This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is funding research to determine the genetic relatedness and effective population size of invasive Aedes aegypti mosquito populations, as well as identify genes under selection that contribute to local adaptation. The award totals $329,039 and will be performed by the University of Florida from April 2025 through February...
This Cooperative Agreement award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to engineer paratransgenic bacterial strains that can interfere with the ability of mosquitoes to transmit malaria parasites. The key objectives are to: Engineer paratransgenic strains of Asaia bogorensis bacteria that lack antibiotic resistance genes, are resistant to horizontal transfer, and secrete...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $211,038 to The Johns Hopkins University to conduct research targeting a reductive dehalogenase enzyme as a new strategy for controlling mosquito populations. The goal is to explore how inhibition of this enzyme or accumulation of certain halotyrosines can suppress mosquito fertility, as a mechanism orthogonal to...
This federal Project Grant award for $245,895.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to discover novel pathways that promote flavivirus infection. The project will use CRISPR-Cas9 base editing approaches to systematically assess the function of ubiquitination sites and enzymes in the context of West Nile virus (WNV) infection. Specific aims include conducting...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $299,969 Project Grant to L2 Diagnostics LLC under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to evaluate a mosquito salivary protein, AGBR1, as a potential vaccine candidate against Chikungunya virus, an arboviral disease transmitted by infected mosquitoes. The project aims to conduct comparative assessments of different AGBR1 vaccine formulations, including...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) in the amount of $433,303 to the Trustees of Indiana University, doing business as Indiana University Indianapolis, to develop an eco-friendly mosquito control solution. The project aims to develop a "Yeast Endless Soda (YES) Feeding Station" that can effectively deliver RNA interference-based insecticides as attractive targeted sugar...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $512,581 to Iowa State University to examine the influence of prostaglandin E2 (PGE2) on cellular and humoral immunity in the mosquito Anopheles gambiae. The key objectives are to: 1) investigate the cellular and transcriptional events following PGE2 activation, 2) examine the mechanisms of PGE2-mediated immune...
This Project Grant award, valued at $792,687.00 and issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to define the structural features of sialoglycans necessary for influenza A virus (IAV) infection and adaptation across various host species. The key activities under this award include: 1) using CRISPR/Cas9 techniques to truncate different types of sialoglycans in human lung...
This $505,238 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to identify skin-associated compounds that can disrupt mosquito landing and biting behavior. The overarching goal is to discover new chemical compounds that can act as improved topical insect repellents compared to DEET, especially for use in tropical regions. The research will involve validating...
This $222,500 Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will support the development of a modular system for delivering CRISPR-based genome and epigenome editing tools in mice. The key products to be delivered under this grant include: Creating mouse lines that express CRISPR-associated proteins (dCas9 and nCas9) with protein ligation tags, which can efficiently combine with accessory editing proteins delivered via...