Project Grant R01AI184785
Award Date
7/9/25
Completion Date
6/30/29
Dollars Obligated
$3.4M
Federal Agency
National Institute of Allergy and Infectious Diseases
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Pensilvania, EE. UU.
Similar Awards
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $226,980.00 to Thomas Jefferson University over a 2-year period starting February 1, 2025. The funding supports research to determine the role of the GPR15-C10ORF99 pathway in T cell homing to the esophagus and the pathogenesis of eosinophilic esophagitis (EoE). The research aims to investigate if this molecular pathway is required for T cell...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $658,426 to The Children's Hospital of Philadelphia (CHOP) to conduct research on chronic STAT3 signaling and its impact on CD8 T cell dysfunction. The key objectives are to investigate the role of the CD39/adenosine axis in impairing CD8 T cell function in the context of STAT3 gain-of-function (GOF) disease, and to...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,485,507 to The Children's Hospital of Philadelphia (CHOP) to conduct research on the role of CD73 in esophageal epithelial homeostasis. The 4-year project aims to: 1) define the requirement of squamous epithelial CD73 in esophageal homeostasis and response to eosinophilic esophagitis...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $936,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The 5-year grant, which commenced on August 12, 2024, will support research to elucidate the regulation and function of tissue-resident eosinophils in allergic microenvironments. The project aims to 1) target cell cycle machinery to manipulate eosinophil specialization, 2) delineate pre-...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $151,444 to The Children's Hospital of Philadelphia (CHOP) to study the development of pediatric allergic diseases and create allergy prediction models using electronic health record (EHR) data. The overarching goal is to improve outcomes in pediatric allergy by understanding the heterogeneous "allergic...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate the mechanisms by which the aryl hydrocarbon receptor (AhR) mediates both protective and detrimental effects on eosinophilic esophagitis (EoE), an allergic disease of the esophagus. The $1,246,628 award, effective from August 15, 2024 through June 30, 2029, will support the...
This $183,600 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research conducted by the University of Utah to investigate the impact of dietary changes on the gut microbiome and its relationship to eosinophilic esophagitis (EoE). The 5-year research project aims to: 1) characterize the fecal microbial composition, gene expression, and metabolites associated with...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $2,119,505.00 to Temple University to conduct research on the role of mitochondria in the pathogenesis of eosinophilic esophagitis (EoE). The research aims to elucidate the direct molecular mechanisms through which the cytokine IL-13 regulates mitochondrial biology in esophageal...
This federal Project Grant award of $716,281.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Children's Hospital Corporation, doing business as Boston Children's Hospital. The grant supports research to investigate the mechanisms by which T regulatory cells control allergic skin inflammation, particularly in the context of atopic dermatitis. The research aims to understand how the...
This federal Project Grant award of $202,314 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support a 5-year research program to investigate the mechanisms of increased intestinal epithelial cell (IEC) barrier permeability in peanut allergy. The research will utilize a novel mouse model and primary human intestinal cell cultures to examine how alterations in the gut microbiome and IEC...