Project Grant R01AI183372
- This federal Project Grant award for $133,800 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to unravel protein trafficking in Trypanosoma cruzi, the causative agent of Chagas disease. The primary objectives are to fully understand protein trafficking mediated by Rab proteins through the contractile vacuole complex (CVC) of the parasite, as well as investigate the role of ceramide in...
- This Project Grant award of $435,875.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of California, Merced to investigate the genetic and molecular mechanisms underlying humoral immunity to the parasitic infection Toxoplasma gondii. The research aims to define how the transcription regulator IKBNS, encoded by the gene NFKBID, mediates protective antibody responses against this pathogen....
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Fundacion Instituto De Investigaciones Biotecnologicas, a non-profit research institute in Argentina. The $133,746 grant, awarded on September 9, 2025, supports high-throughput analysis of dynamics of antibody responses against defined epitopes to prioritize diagnostic and prognostic markers for Chagas disease. The research...
- This $426,250 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to investigate the function of two peroxisome-derived proteins, PEX4 and PEX22, in apicomplexan parasites like Plasmodium falciparum and Toxoplasma gondii. These parasites cause major infectious diseases such as malaria and toxoplasmosis. The research aims to improve understanding of...
- This $412,581 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research on specialized mitochondrial DNA polymerases in African trypanosomes - parasites that cause neglected tropical diseases such as human African trypanosomiasis, Chagas disease, and leishmaniasis. The project aims to clarify the roles of two trypanosome-specific DNA polymerases (POLIB and POLID) in maintaining the parasite's...
- This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA Program 93.855 - Allergy and Infectious Diseases Research, will support research to investigate the genetic mechanisms that determine host susceptibility to low virulence strains of the Toxoplasma gondii parasite in mice. The $269,054 award, effective November 8, 2024 through October 31, 2026, will enable researchers at the University of California, Merced to leverage the...
- This $570,760 project grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by President and Fellows of Harvard College (Harvard Medical School) to investigate the molecular mechanisms and structural features of intraflagellar transport (IFT) in trypanosomatid parasites like Leishmania. The research aims to reveal conserved and parasite-specific aspects of IFT, identify new adaptor proteins that...
- This $563,513 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research at Arizona State University (ASU) to investigate the patterning, growth, and maturation of the cortical microtubules in the parasitic Toxoplasma species. The goal is to develop a better understanding of the cellular architecture of these unicellular parasites, which can cause diseases like...
- This federal Project Grant award of $791,864 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify molecular factors controlling chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The research aims to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, with the goal...
- This $817,730 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports the development of new tools to study how the protozoan parasite Toxoplasma gondii delivers effector proteins into host cells during the invasion process. The research aims to understand the mechanism by which T. gondii, which infects 30% of the human population, translocates these proteins across the host cell membrane to subvert...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $133,693 to Fundacion Instituto De Investigaciones Biotecnologicas, a non-profit research institute in Argentina, to study the role of an unusual variant nucleosome in the life cycle of the Toxoplasma gondii parasite. The research aims to understand how epigenetic changes in gene expression, facilitated by the parasite's unique H2A.Z/H2B.Z double-variant nucleosome, allow it to adapt to various environmental stresses and complete its life cycle. This project promises to provide valuable insights into the parasite's adaptive strategies and may identify potential therapeutic targets. The award period runs from August 2025 to July 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $133.7k | 8/25/25 |