Project Grant R01AI183370
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Fundacion Instituto De Investigaciones Biotecnologicas, a non-profit research institute in Argentina. The $133,746 grant, awarded on September 9, 2025, supports high-throughput analysis of dynamics of antibody responses against defined epitopes to prioritize diagnostic and prognostic markers for Chagas disease. The research...
- This federal Project Grant award for $133,800 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to unravel protein trafficking in Trypanosoma cruzi, the causative agent of Chagas disease. The primary objectives are to fully understand protein trafficking mediated by Rab proteins through the contractile vacuole complex (CVC) of the parasite, as well as investigate the role of ceramide in...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $449,408 Project Grant under CFDA 93.855 - Allergy and Infectious Diseases Research to Duke University to develop diagnostic antibodies for acute and chronic Chagas disease. The funding will support the generation of a panel of antibodies capable of detecting Trypanosoma cruzi, the parasite that causes Chagas disease, in blood samples. This work aims to address the lack of effective rapid diagnostic tests for Chagas...
- This $412,581 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research on specialized mitochondrial DNA polymerases in African trypanosomes - parasites that cause neglected tropical diseases such as human African trypanosomiasis, Chagas disease, and leishmaniasis. The project aims to clarify the roles of two trypanosome-specific DNA polymerases (POLIB and POLID) in maintaining the parasite's...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $133,693 to Fundacion Instituto De Investigaciones Biotecnologicas, a non-profit research institute in Argentina, to study the role of an unusual variant nucleosome in the life cycle of the Toxoplasma gondii parasite. The research aims to understand how epigenetic changes in gene expression, facilitated by the parasite's unique H2A.Z/H2B.Z...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), is providing $160,500 to Baylor College of Medicine to develop and validate a highly sensitive serological assay for detecting all geographic variances of Trypanosoma cruzi (T. cruzi) infection, the causative agent of Chagas disease. This neglected tropical disease is endemic to Latin America but increasingly...
- This Project Grant award for $440,000.00, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at the University of Texas Medical Branch at Galveston to determine the function and mechanism of the long non-coding RNA CHAST in Trypanosoma cruzi infection and dissemination, which causes Chagas disease. The research aims to investigate how T. cruzi deregulates the CHAST-PLEKHM1 pathway...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) in the amount of $720,588 supports research to develop safe and broadly protective vaccines against New World arenaviruses that can cause severe hemorrhagic fevers in humans. The Regents of the University of Minnesota, as the primary award recipient, will leverage their live-attenuated vaccine technology based on the non-pathogenic Pichinde virus to...
- The University of Cincinnati is the recipient of a $444,688 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research on characterizing cyclic AMP (cAMP) signaling microdomains in the human pathogen Trypanosoma cruzi, which causes Chagas disease. The research aims to investigate the specific roles of the flagellar tip and contractile vacuole complex in regulating cAMP signaling pathways involved...
- This $570,760 project grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by President and Fellows of Harvard College (Harvard Medical School) to investigate the molecular mechanisms and structural features of intraflagellar transport (IFT) in trypanosomatid parasites like Leishmania. The research aims to reveal conserved and parasite-specific aspects of IFT, identify new adaptor proteins that...
This Project Grant award of $123,280 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The goal of the project is to investigate the adaptive immune response against Trypanosoma cruzi, the parasite that causes Chagas disease, in order to develop effective vaccine candidates for dogs and humans. Key activities include analyzing the peptide repertoire presented by dendritic cells during T. cruzi infection, identifying vaccine candidates, and evaluating various vaccination approaches targeting antigen cross-presentation pathways. The project will be performed by the Instituto de Biologia Molecular y Celular de Rosario (IBR) in Argentina, with a performance period from August 2025 to July 2030. IBR has previously received federal grant sub-awards to support its work on disease-causing bacteria and antibiotic tolerance.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $123.3k | 8/25/25 |