Project Grant R01AI183353

Award Date 8/9/24
Completion Date 7/31/29
Dollars Obligated $137K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Thailand
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The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $137,229 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Chulalongkorn University in Thailand. The grant, which runs from August 2024 to July 2029, focuses on two key objectives:

  1. Characterizing the host response and identifying novel biomarkers to accurately predict the severity of acute leptospirosis, a potentially life-threatening zoonotic disease. This will involve a multi-omics analysis of blood samples and clinical data from the university's existing biorepository of 218 confirmed leptospirosis cases.

  2. Identifying risk factors and novel biomarkers for leptospiral chronic kidney disease (CKD) and its progression. This will leverage data from the university's ongoing prospective cohort study and clinical trial involving 160 leptospirosis patients to better understand the mechanisms and risk factors associated with long-term kidney complications.

The research aims to improve early prediction of severe leptospirosis cases and long-term sequelae, which is critical for reducing mortality and improving patient outcomes in endemic tropical regions.

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