Mitigating ischemia-reperfusion injury to reduce early damage to intestinal allografts

Active Project Grant Awarded Last action

Award ID
R01AI182590
Recipient
Awarding agency
Obligated
$4,390,356

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 56% complete
Place of performance
Raleigh, NC 27695, USA

Award details come from USAspending.gov.

Description

Abstract
Intestinal failure results from conditions such as trauma-related small bowel injury, necrotizing enterocolitis, and inflammatory bowel disease. Treatment options are limited; however, an important emerging therapeutic approach is intestinal transplantation (IT). When successful, IT is associated with marked improvements in quality of life and overall well-being. However, its current success rate is

Transactions

Action Obligated Date
Amendment $725,633
Amendment $707,388
Amendment $707,388
Amendment $74,147
Amendment $74,147
Amendment $700,551
Amendment $700,551
Original award $700,551

Subawards

Subrecipient Amount Awarded
Duke University A consortium agreement with Duke University and NC State University will be established to provide abdominal transplant surgery expertise for the NIH R01… $70,156
Duke University $194,582
Duke University This project investigates the use of normothermic machine perfusion (NMP) in mitigating inchemia-reperfusion injury to intestinal allografts. $76,199
Functional Circulation LLC Develop and provide a 3-syringe infusion device to be integrated with the existing perfusion system to provide precise, manually controlled introductions of… $31,685

Quick answers

Who received award R01AI182590?

R01AI182590 was awarded to North Carolina State University by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on February 1, 2024.

How much is award R01AI182590 worth?

$4,390,356 has been obligated on R01AI182590.

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