Arbovirus transmission dynamics across a metapopulation undergoing environmental and social change
Active Project Grant Awarded Last action
- Award ID
- R01AI182408
- Recipient
-
Regents Of The University Of Michigan UEI GNJ7BBP73WE9
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,052,425
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 39% complete
- Place of performance
- Ann Arbor, MI 48109, USA
Award details come from USAspending.gov.
Description
- Abstract
- Aedes-borne viral diseases are associated with explosive urban epidemics, but rural transmission is undergoing expansion and its role in virus maintenance is poorly understood. Transmission dynamics at a regional level requires US to go beyond conceptualizing dengue as urban or rural, terms that are administrative and political rather than etiologic. Borrowing from metapopulation theory, the transmission dynamics of dengue are better analyzed using spatial terms like patches that describe environmental, social, and biological dynamic processes at multiple scales. Our overall hypothesis is that dengue and zika virus (denv, zikv) transmission dynamics occur at multiple geographic scales, driven by connections among human movement patterns, social networks, and mosquito densities at fine scales (within locations) and by regional, national, and international transportation networks at larger scales. Given its relevance we will study denv as the predominant pathogen; given the immune imprint that zikv leaves, we will include IT and monitor any other aedes-borne viruses that may circulate or emerge in any given year. The relative contribution of intra- and inter-location movements depends on key geolocatable characteristics that we categorize as landscapes (e.g., weather, structural and surface features), bioscapes (e.g., mosquito behavior and human immunity), and socioscapes (e.g., movement, social networks). We propose to study denv transmission dynamics in northwestern coastal ecuador where communities reside in a heterogeneous array of changing environments and where we have documented very recent introduction and establishment of denv as well as high zika seroprevalence. We will address our overarching hypotheses through parallel longitudinal cohorts of human (aim 1) and vector (aim 2) populations in regionally representative communities to characterize the transmission dynamics at multiple geographic scales (aim 3). Aim 1 focuses on the question: what is the force of denv infection and the rate of virus introduction across the diverse landscape within 6 communities (across a remoteness gradient)? Aim 2 focuses on the question: how do key entomological parameters (vector bioscape) drive local denv transmission within distinct landscapes of unique interconnected communities in northwestern ecuador? And aim 3 focuses on the question: can a collection of smaller communities, connected through a transportation and social network, function (SOCIOSCAPE) like a larger population center to sustain and seed transmission? This R01 will provide fundamental insights into how a changing environment influences heterogeneous transmission patterns as well as epidemiological and immunological interactions between denv and zikv. These insights can provide information crucial to developing optimal control strategies for aedes-borne diseases.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $255,461 | |
| Amendment | $398,286 | |
| Amendment | $699,339 | |
| Original award | $699,339 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Universidad San Francisco De Quito Usfq | $255,461 | |
| University Of California Irvine | $61,299 | |
| The Regents Of The University Of California | $241,789 | |
| University Of California, Davis | $88,263 | |
| Universidad San Francisco De Quito Usfq | $243,595 |
Quick answers
Who received award R01AI182408?
R01AI182408 was awarded to Regents Of The University Of Michigan by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on November 19, 2024.
How much is award R01AI182408 worth?
$2,052,425 has been obligated on R01AI182408.
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