This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the development of a comprehensive strategy to neutralize C. difficile toxin B (TcdB) and prevent C. difficile infection (CDI). The $709,629 award to North Carolina State University aims to: Elucidate the molecular mechanism of the SB6 neutralizing peptide's inhibition of TcdB. This knowledge will inform the design of...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $1,541,024.00 to the University of Notre Dame to support research on the spore germination pathway of the bacterium Clostridioides difficile (C. difficile) and its pharmacological intervention. The research aims to elucidate the details of the spore germination process, demonstrate that inhibiting spore germination is key to preventing...
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded Biotherapeutics, Inc. a $300,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to accelerate the development of a novel, antimicrobial-free therapeutic for Clostridioides difficile infection (CDI). The project aims to conduct head-to-head comparisons of the efficacy of Biotherapeutics' product candidate versus FDA-approved CDI treatments in recurrent mouse models. Key objectives...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is intended to investigate the role of commensal gut microbiota in protecting against Clostridioides difficile infection (CDI) and identifying microbiome characteristics that may synergize with prebiotic treatments. The $252,666 award supports research to develop clinically-relevant animal models that integrate both diverse...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop a novel probiotic yeast-based immunotherapy to prevent the transmission of Clostridioides difficile (C. difficile) infections. The $511,553 award will fund the screening and generation of bi-specific antibodies targeting the C. difficile surface protein CWP84, which are critical for bacterial colonization and...
This $502,500 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to elucidate the molecular basis of ferrosome organelle biogenesis in the bacterium Clostridioides difficile and its impact on host-microbe interactions. The research aims to investigate the mechanisms of ferrosome formation, which serve as an iron storage system that allows C. difficile to adapt to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), awarded under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $672,063 to the University of South Florida (USF) to support the "Development of Probiotic-Based and Clostridioides Difficile-Targeted Therapeutics". The award period runs from May 28, 2024 to March 31, 2026. The primary goal of this project is to develop novel non-antibiotic therapeutics that...
This $2,237,543 federal Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant will fund a quantitative investigation of the pathogen-microbiome-host dynamics of clinically prominent Clostridioides difficile (C. diff) lineages and their contribution to C. diff infection (CDI). The research aims to: 1) Investigate pangenome determinants of CDI risk in clinically...
This $780,162 Project Grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases will fund research at Old Dominion University from August 2022 through July 2026 exploring the role of nutrient and stress sensing in regulating Clostridioides difficile physiology and behavior within the host. The research aims to determine how the stringent response regulates disease-relevant bacterial processes and characterize enzymes that mediate alarmone metabolism...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $261,492 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Trustees of Tufts College (Tufts University School of Medicine) to support research on the epigenetic regulation of sporulation in Clostridioides difficile, a major nosocomial pathogen. The project aims to identify specific methylation sites that mediate the epigenetic regulation of sporulation in C. difficile, which could facilitate...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) is for the development of novel antibiotic therapies targeting Clostridioides difficile infection (CDI). The $754,446 award aims to:
Optimize a lead series of inhibitors targeting the essential bacterial enzyme FabK, with the goal of improving antimicrobial potency and selectivity against C. difficile.
Identify new chemical compounds that can inhibit FabK as potential new treatments for CDI.
Evaluate the in vivo efficacy and microbiome impact of lead FabK inhibitor compounds in animal models of recurrent CDI.
The project seeks to advance a new class of narrow-spectrum antibacterials that can selectively target C. difficile while minimizing disruption to the gut microbiome, representing a promising approach to address the urgent challenge of rising drug-resistant, hypervirulent CDI strains. The funding period for this award is from December 2024 to November 2029.