A novel approach of age-grading of mosquitoes using sers and machine learning models
Active Project Grant Awarded Last action
- Award ID
- R01AI180243
- Recipient
-
University Of Massachusetts UEI VGJHK59NMPK9 Part of Massachusetts University Of
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,281,317
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 59% complete
- Place of performance
- Hadley, MA 01035, USA
Award details come from USAspending.gov.
Description
- Abstract
- Mosquito-borne pathogens, including malaria, zika, dengue, and chikungunya continue to be a major public health concern globally. As only older mosquitoes are infectious and represent a risk to human health, scientists have sought to age-grade mosquitoes based on this understanding; however, no reliable, cost effective and practical methods exist to age mosquitoes despite the tremendous epidemiological value of this approach. The overall objective of this R01 is to establish a novel approach to age-grade mosquitoes aedes aegypti in the field. The approach we took is based on surface-enhanced raman spectroscopy (SERS) to analyze the biomolecules from mosquito water extract that are bound with silver nanoparticles (AGNPS) and then the SERS spectra are used in modern machine learning models to age-grade the mosquitoes. Our central hypothesis is that AGNPS interact with specific biomolecules enabling SERS to generate unique and predictable spectral information for establishing modern machine learning models to determine the age of mosquitoes. Our prior work demonstrates the feasibility of SERS and artificial neuron networks (ANNS) to determine the age of both lab (error
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $370,265 | |
| Amendment | $364,013 | |
| Amendment | $364,013 | |
| Amendment | $40,794 | |
| Amendment | $40,794 | |
| Amendment | $367,146 | |
| Amendment | $367,146 | |
| Original award | $367,146 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Cornell University | $147,809 | |
| Georgia TECH Research Corp | $51,295 | |
| W03K W Reedarmyinstrsch(Wrair) | $217,196 | |
| Georgia TECH Research Corp | $32,286 |
Quick answers
Who received award R01AI180243?
R01AI180243 was awarded to University Of Massachusetts by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on December 15, 2023.
How much is award R01AI180243 worth?
$2,281,317 has been obligated on R01AI180243.
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