The federal Project Grant award R21AI183127, totaling $423,500.00, was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The primary goal of this 2-year award to Loyola University of Chicago is to develop novel antibodies that specifically target autoreactive B cells as a potential therapeutic approach for treating systemic lupus erythematosus (SLE), particularly in African American patients...
This Project Grant award of $413,860, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to investigate the interactions between non-tuberculous mycobacteria (NTM) infections, specifically Mycobacterium abscessus (MAB), and the onset/progression of systemic lupus erythematosus (SLE). The research will utilize preclinical mouse models and ex vivo models with fetal...
The University of Michigan received a $1,540,008 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on June 5, 2025. The grant, titled "Integrated Program for Cutaneous Immune-Stromal Interactions in SLE (IPCISS)", supports interdisciplinary translational research on systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE). The program aims to: 1) develop knowledge of the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $555,774.00 to the University of Alabama at Birmingham (UAB) over a 5-year period starting November 19, 2024. The award supports research to investigate the role of the aryl hydrocarbon receptor (AhR) pathway in regulating the development of T-bet+ B cells, which are implicated in the pathogenesis of systemic lupus...
This $600,000 project grant from the National Institute of Allergy and Infectious Diseases will support General Nanotherapeutics LLC's development of nanoimmunotherapy for chronic immune-mediated diseases. The company will leverage nanoparticles to target and expand immunoregulatory cells ex vivo and assess their ability to suppress effector immune responses and induce remission in vivo, including in a lupus model. This proof-of-concept work aligns with the Allergy and Infectious Diseases...
The University of Chicago was awarded a $506,394 Project Grant by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on January 24, 2025. The grant supports research to define the mechanisms by which bacterial cholesterol-dependent cytolysins can reorganize host cell organelles and activate the NLRP3 inflammasome signaling pathway, which plays a critical role in the immune response to bacterial infections. The research aims to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Program (CFDA 93.855), provides $256,808 to the University of Washington to investigate the role of dysregulated mRNA splicing in systemic lupus erythematosus (SLE). The goal is to better define the molecular mechanisms that cause and perpetuate SLE by examining altered protein structures and neoepitopes in lupus neutrophils. The research...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,205,213 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The grant, titled "Deciphering Immunopathogenesis of Mucormycosis to Advance Risk Stratification, Diagnosis and Management of the Disease", aims to improve understanding of the immune response and pathogenesis of mucormycosis, a...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $267,310 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Illinois in Chicago. The grant, awarded on August 27, 2024, supports research to evaluate the role of a lipoic acid transfer protein in Staphylococcus aureus metabolism and virulence. The project aims to determine how this lipoic acid transfer protein interfaces with other metabolic enzymes to control...
This $793,093 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to define the regulatory landscape of systemic lupus erythematosus (SLE) and its cardiovascular disease (CVD) comorbidity. The grantee, Oklahoma Medical Research Foundation, will conduct systematic, high-throughput studies in macrophages derived from induced pluripotent stem cells to identify genetic variants that disrupt regulatory...