Genomics and sero-epidemiology of plasmodium falciparum malaria in a pre-elimination setting
Active Project Grant Awarded Last action
- Award ID
- R01AI176569
- Recipient
-
Pontificia Universidad Catolica Del Ecuador UEI VVBMS2GLHL33
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $801,171
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 71% complete
- Place of performance
- Ecuador
Award details come from USAspending.gov.
Description
- Abstract
- Malaria continues to severely impact public health in countries around the world. Some countries like ecuador made impressive progress in the first 10-15 years of this century. Nevertheless, recent years have seen stagnation and malaria cases are increasing again. While most cases of plasmodium falciparum in northwest ecuador appear to originate in the pacific coast of colombia, asymptomatic reservoirs of this parasite are common and may be important in maintaining transmission within ecuador. One of the main problems for malaria elimination is the presence of asymptomatic reservoirs. To better understand the malaria transmission dynamics in this pre-eliminating region, we will characterize the genetics of the parasites circulating in northwest ecuador (symptomatic and asymptomatic), identify serological biosignatures of infection and define the relationships between the clinical outcome of the infection, parasite genetics and serological markers. Lastly, we will validate the role of acquired immunity in disease severity, clonal persistence, and outbreak emergence through innovative in vitro assays. This project will inform local control decisions in ecuador, and, most importantly, provide a model for understanding disease persistence in other pre-elimination settings around the world.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $135,138 | |
| Amendment | $136,629 | |
| Amendment | $135,262 | |
| Amendment | $135,262 | |
| Amendment | $129,440 | |
| Original award | $129,440 |
Quick answers
Who received award R01AI176569?
R01AI176569 was awarded to Pontificia Universidad Catolica Del Ecuador by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on April 1, 2023.
How much is award R01AI176569 worth?
$801,171 has been obligated on R01AI176569.
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