Project Grant R01AI176494

Award Date 4/17/23
Completion Date 3/31/28
Dollars Obligated $408K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
South Africa
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This federal Project Grant award of $233,528 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to delineate the transcriptomic responses in human peripheral blood and stool samples collected from volunteers after controlled infection with varying doses of two different strains of norovirus. The goal is to use these early innate transcriptional responses as predictors of the effective adaptive...
The federal Project Grant award R21AI185887 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $516,900 grant awarded to Immport Therapeutics Inc. (doing business as Antigen Discovery Inc.) supports research to discover antibody correlates of protection against five common enteric viruses that cause diarrhea in infants, including adenovirus, astrovirus, norovirus, rotavirus, and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $798,173 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The Ohio State University. The 5-year grant, running from May 2025 to April 2030, will support the development of novel multivalent mucosal vaccines for human noroviruses (HuNoVs), a leading cause of acute gastroenteritis worldwide. The project aims to develop live-vectored mucosal HuNoV vaccines using the FDA-approved...
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This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the prevalence, clinical impact, and virus-host dynamics of SARS-CoV-2 and respiratory virus co-infections in children. With total funding of $2,353,903 over the award period from July 2024 to May 2029, the project aims to: 1) assess the prevalence of SARS-CoV-2 and respiratory...
This $188,980 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 (Allergy and Infectious Diseases Research) is funding research at The Washington University in Missouri to elucidate the role of intestinal M cells in rotavirus enteric infection, systemic dissemination, and pathogenesis. The key objectives are to determine the extraintestinal tissues and cell types targeted by rotavirus following oral inoculation, as well as to utilize a...
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GASTROENTERITIS VIRUS INFECTIONS IN SOUTH AFRICAN CHILDREN: SECRETOR STATUS-LINKEDSUSCEPTIBILITY, PREVALENCE AND GENETIC DIVERSITY AND HUMORAL RESPONSES TO NOROVIRUSINFECTION - ABSTRACT NOROVIRUS, ROTAVIRUS AND ADENOVIRUS ARE THE MAJOR CAUSES OF SEVERE VIRAL GASTROENTERITIS IN CHILDREN WORLDWIDE. THIS PROJECT AIMS TO MONITOR THE PREVALENCE, GENETIC DIVERSITY, PREDOMINANT AND EMERGING STRAINS OF THESE VIRUSES IN SOUTH AFRICA (SA) OVER A 5-YEAR PERIOD. IN ADDITION, THE PROJECT WILL INVESTIGATE THE HUMORAL RESPONSE TO NOROVIRUS INFECTIONS AND DETERMINE TO WHICH NOROVIRUS GENOTYPES CHILDREN IN SA ARE EXPOSED TO IN THE FIRST TWO YEARS OF LIFE, AND WHEN PROTECTIVE ANTIBODIES ARE GENERATED. WE WILL PERFORM PARALLEL GASTROENTERITIS VIRUS SURVEILLANCE 1) IN CHILDREN (

Posted 4/17/23, 12:00 AM