Estimation of risk associated with zoonotic tuberculosis in south india

Active Project Grant Awarded Last action

Award ID
R01AI170753
Recipient
Awarding agency
Obligated
$3,711,991

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 55% complete
Place of performance
State College, PA 16802, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Tuberculosis (TB) in humans results from infection with members of the mycobacterium tuberculosis complex (mtbc). The disease is endemic in many parts of the world. So is bovine tuberculosis (BTB) - a well-recognized zoonotic disease of bovine species (cattle and buffalo) also caused by infection with members of the mtbc. India has the world's highest TB burden in humans, with more than 2M new cases and 400,000 TB-related deaths each year. India also hosts the largest bovine herd on the planet (~300M animals), and our recent studies suggest that more than 22M of those animals may suffer from BTB. Yet the risk of zoonotic TB (ZTB) resulting from transmission of mtbc from bovines to humans in india and other high-TB burden settings is unknown. This is a major knowledge GAP, and elimination of TB will be considerably more difficult if there is spillover from a domestic livestock reservoir to humans. This is of particular concern in countries such as india where the frequent consumption of unpasteurized milk and close contact with infected animals likely present additional elevated risks for zoonotic transmission. Because of this, the world health organization (who) and other supranational organizations have developed a "roadmap for zoonotic TB" that calls for the establishment of a stronger evidence base to improve understanding of the burden and risk pathways of ZTB to guide an effective response. To fill these knowledge gaps, we propose studies with the overall objective of estimating the risk associated with ZTB in a high-TB-burden setting. We will accomplish this by applying rigorous quantitative risk assessment augmented by state-of-the-art whole-genome sequence (WGS)-based molecular epidemiology and multi-host transmission modeling. Performed at well-established study sites in vellore and tiruvallur districts in tamil nadu, india, our specific aims are to: 1) estimate the risk of human TB associated with exposure to cattle, buffalo, or the consumption of raw milk in ~1,750 human cases and ~3,500 controls; 2) apply WGS-based approaches to define the genetic diversity and molecular epidemiology and perform phylodynamic and phylogeographic analysis of mtbc lineages circulating in human TB cases, sympatric cattle and buffalo, and locally sourced raw milk; and 3) perform multi-host transmission modeling to quantitatively assess ZTB risk to humans and the potential benefits of control. These studies involve the application of innovative and powerful nested case-control epidemiological surveys with WGS-based genotyping and mathematical modeling. The results of our studies will inform and refine estimates of ZTB risk, enable identification of transmission chains at a local scale, and transform our understanding of spillover and circulation of mtbc strains between human and bovine hosts. In the long-term, our findings will provide sustained positive impact through the development of evidence-based approaches to quantify and reduce risk of ZTB in support of the global efforts to end TB.

Transactions

Action Obligated Date
Amendment $85,074
Amendment $85,563
Amendment $409,647
Amendment $573,487
Amendment $573,487
Amendment $60,640
Amendment $60,640
Amendment $621,151
Amendment $621,151
Original award $621,151

Subawards

Subrecipient Amount Awarded
The Christian Medical College Vellore Association Collaboration on, "Estimation of risk associated with zoonotic tuberculosis in South India." $85,074
National Institute For Research In Tuberculosis $85,563
The Chancellor, Masters, And Scholars Of The University Of Cambridge $229,435
The Research Institute Of The Mcgill University Health Centre $122,745
Tamilnadu Veterinary And Animal Sciences University $38,508
The Christian Medical College Vellore Association $149,522
The Chancellor, Masters, And Scholars Of The University Of Cambridge $110,068
Cisgen Biotech Discoveries Private LIMITED $110,075
The Research Institute Of The Mcgill University Health Centre $59,051
The Christian Medical College Vellore Association Collaboration on, "Estimation of risk associated with zoonotic tuberculosis in South India," $83,334
National Institute For Research In Tuberculosis Collaboration on, "Estimation of risk associated with Zoonotic tuberculosis in South India." $68,642
The Chancellor, Masters, And Scholars Of The University Of Cambridge Collaboration on, "Estimation of risk associated with zoonotic tuberculosis in South India." $101,045
The Research Institute Of The Mcgill University Health Centre $54,946
Cisgen Biotech Discoveries Private LIMITED $46,766
The Christian Medical College Vellore Association $74,476
Show all 15

Quick answers

Who received award R01AI170753?

R01AI170753 was awarded to The Pennsylvania State University by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on February 20, 2024.

How much is award R01AI170753 worth?

$3,711,991 has been obligated on R01AI170753.

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