The effect of HIV on sars-COV-2 transmission and emergence of variants of concern

Active Project Grant Awarded Last action

Award ID
R01AI170204
Recipient
Awarding agency
Obligated
$3,589,266

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 86% complete
Originally
Place of performance
Irvine, CA 92697, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The emergence and spread of sars-COV-2 variants of concern is threatening global health and our ability to prevent covid-19 disease, raising concerns about a potential new wave of the pandemic. HIV may complicate the trajectory of the covid-19 pandemic and efforts to eradicate the virus. While most people with a competent immune system successfully clear sars-COV-2 infection within days, people living with HIV with weakened immunity can carry persistent infection for months. Individuals with immunodeficiency may also have a higher risk of sars-COV-2 reinfection that can further extend the duration of infectiousness with high viral load. As a result, chronically infected individuals are potentially contagious for an extended period of time and may sustain transmission in the community. Similar to other viruses, sars-COV-2 accumulates mutations over time as IT replicates within the host. Therefore, chronic sars-COV-2 infection in the context of a weakened immune system may provide the time and the environment needed for the virus to replicate and evolve genetic mutations associated with survival advantages, including increased transmissibility and resistance to covid-19 vaccines or treatment. The proposed research aims to understand the overall impact of HIV infection on the sars-COV-2 viral evolution and transmission dynamics in a setting with high HIV prevalence. We will address current knowledge gaps by integrating sars-COV-2 genomic data, patient-level clinical data, and epidemiological data to achieve the following aims: 1) we will determine the effect of HIV infection on the transmission dynamics of covid-19 and emergence of sars-COV-2 variants; and 2) we will determine the effect of HIV-associated immunosuppression on the acquisition of sars-COV-2 mutations. For the first aim, advanced phylodynamic methods will be applied to determine how HIV affects the transmission and viral evolution of sars-COV-2 on a population scale, as well as to describe risk factors that drive individual and population-level covid-19 transmission. For the second aim, we will recruit and follow a cohort of covid-19 patients with and without HIV infection to determine the effect of HIV-associated immunosuppression on the rate of emerging sars-COV-2 mutations. The proposed research will also utilize active case finding to minimize sampling bias. Findings from this project will inform the development of optimal public health interventions to control the pandemic by disrupting transmission chains and prevent the emergence and spread of alarming variants.

Transactions

Action Obligated Date
Amendment $0
Amendment $201,406
Amendment $360,093
Amendment $145,607
Amendment $565,009
Amendment $565,009
Amendment $559,720
Amendment $596,211
Original award $596,211

Subawards

Subrecipient Amount Awarded
University Of Texas Medical Branch At Galveston Stephen Molldrem, PhD (Project Director, 1.8 calendar months). Dr. Molldrem will be the Project Director of the study. He will oversee all aspects of study… $56,976
Botswana Institute For Technology Research And Innovation LIMITED BITRI will be a subaward recipient for the duration of the project period. BITRI is a Botswana-based institution affiliated with the Botswana Ministry of Health… -$144,293
Victus Global Botswana Organisation VGBO will be a subaward recipient for the duration of the project period. VGBO is a Botswanabased non-profit organization founded by Dr. Chawangwa Modongo,… $144,293
University Of Texas Medical Branch At Galveston Stephen Molldrem, PhD (Project Director, 1.8 calendar months). Dr. Molldrem will be the Project Director of the study. He will oversee all aspects of study… $45,003
Botswana Institute For Technology Research And Innovation LIMITED BITRI will be a subaward recipient for the duration of the project period. BITRI is a Botswana-based institution affiliated with the Botswana Ministry of Health… $70,684
Victus Global Botswana Organisation Scope of Work Victus Global Botswana Organisation (VGBO) VGBO will be a subaward recipient for the duration of the project period. VGBO is a Botswana- based… $86,354
Victus Global Botswana Organisation Scope of Work Victus Global Botswana Organisation (VGBO) VGBO will be a subaward recipient for the duration of the project period. VGBO is a Botswanabased… $267,957
Forschungszentrum Borstel Leibniz Lungenzentrum Research Center Borstel (RCB) is the recipient institution for this subaward. RCB is one of the world's leading institutions on sequencing of pathogen genome… $123,817
Botswana Institute For Technology Research And Innovation LIMITED BITRI will be a subaward recipient for the duration of the project period. BITRI is a Botswana-based institution affiliated with the Botswana Ministry of Health… $121,662

Quick answers

Who received award R01AI170204?

R01AI170204 was awarded to University Of California Irvine by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on July 5, 2022.

How much is award R01AI170204 worth?

$3,589,266 has been obligated on R01AI170204.

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