Finishing HIV: an EHE model for latinos integrating one-stop-shop prep services, a social network support program and a national pharmacy chain
Active Project Grant Awarded Last action
- Award ID
- R01AI169643
- Recipient
-
University Of Miami UEI F8THLJQSAF93 Part of University Of Miami
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $5,208,957
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 73% complete
- Originally
- Place of performance
- Miami, FL 33136, USA
Award details come from USAspending.gov.
Description
- Abstract
- Overview and background. This is a proposal for a hybrid 2 implementation-effectiveness randomized controlled trial (RCT) of finishing HIV, an implementation strategy bundle of a social network support component and a one-stop-shop prep component to improve prep initiation of latino men who have SEX with men (lmsm). Prep can reduce HIV transmission by up to 99%,1 however, prep services are not being sufficiently accessed by latinos in miami, the epicenter of the HIV epidemic in the US.2 further, lmsm who do not self-identify as GAY have lower prep awareness than lmsm who self-identify as GAY.3 to prepare for this study, we have developed an innovative approach that tailors lmsm engagement based on sexual self-identity using community-based social events and pharmacies. Preliminary work. The trial is a direct next step from our "ending the HIV epidemic" (EHE) planning supplements, where we conducted the needed preliminary study to launch this hybrid trial, and with ISCI3 support, the team jointly assessed feasibility, refined strategies and built a logic model informed by local context needs and preferences. Over the past two years, the PI has built partnerships with latinos salud (a local HIV agency for lmsm) and CVS health. Design. We will use an innovative network-based approach informed by the PI's K99/R00 funded research and social contagion theory,4 which states that health behavior preferences, including prep initiation, are affected by opinions and attitudes prevailing in one's social environment, and spread through friendship networks.5 penetration at pharmacies and social events will lead to random assignment of the participants to either finishing HIV (social network support component + one-stop-shop prep component; n=24 seeds and 288 lmsm friends) or to standard health promotion (n=312). Participants will be assessed at baseline, and receive follow UPS and dried blood spots collection at 6 and 12 months to quantify tenofovir diphosphate concentrations. For implementation (aim 1), we will use RE-aim FRAMEWORK6 to evaluate reach (the extent to which high risk persons initiate participation in the program), and implementation (the extent to which implementation strategies are delivered as designed) of finishing HIV. We will also use consolidated framework for implementation science RESEARCH7 to examine contextual factors associated with reach and implementation (e.g., facilitators and challenges or barriers to reach and implementation; participants reaction to these strategies). We will compare effectiveness (aim 2) of the strategies in prep initiation (primary outcome), as well as prep knowledge, retention, and adherence (secondary outcomes). We will identify theory-based moderators (e.g., recruitment at social events VS. Pharmacies) and social network mediators of intervention effects. We will also assess how friendship network structural evolutions contribute to increasing prep initiation. Implications. Our use of a social network support, one-stop-shop prep, and community and national pharmacy chain partners is a promising model that can be replicated in other EHE priority areas nationwide.
Transactions
| Action | Obligated | Date |
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| Amendment | $866,826 | |
| Amendment | $696,028 | |
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| Amendment | $710,057 | |
| Amendment | $710,057 | |
| Amendment | $710,057 | |
| Amendment | $757,964 | |
| Original award | $757,964 |
Show all 18
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Latinos Salud Inc. | $392,967 | |
| University Of California, San Diego | $132,747 | |
| Yale Univ | $134,507 |
Quick answers
Who received award R01AI169643?
R01AI169643 was awarded to University Of Miami by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on June 23, 2022.
How much is award R01AI169643 worth?
$5,208,957 has been obligated on R01AI169643.
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