Comprehensive characterization of ancestral populations of the vector aedes aegypti on indian ocean islands

Active Project Grant Awarded Last action

Award ID
R01AI155562
Recipient
Awarding agency
Obligated
$5,945,465

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 96% complete
Originally
Funding
  • $5,267,546.00 Federal
  • $677,919.00 Non-federal
Place of performance
New Haven, CT 06511, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
We have recently shown that the ancestors of all aedes aegypti populations in both sub-saharan africa as well as around the world presently reside on islands in the southwest indian ocean (swio) including madagascar. These islands gave rise to continental african AE. Aegypti formosus no earlier than about 100,000 years ago. We propose multidisciplinary studies on swio populations of AE. Aegypti along with its close relatives, AE. Mascarensis and AE. PIA. This will include population genetics, phylogenetics/phylogeography, vector competence, blood meal analyses, and characterization of the virome of field-caught females. We address question such as: are the ancestors that gave rise to AE. Aegypti S.S. Capable of transmitting the same viruses that cause human diseases? Are these mosquitoes carrying the same viruses in the field and/or do they harbor novel undescribed arboviruses? What are the sources of their blood meals? Where do they breed? Population genetics and phylogenetic preliminary work have already identified candidates for new undescribed species and we suspect more cryptic taxa will be found. We propose to assemble complete genomes for the most informative populations/taxa that will allow comparative studies as well as inference of the ancestral genome of AE. Aegypti S.S., a fundamental resource for analysis of a plethora of genomics studies ongoing in laboratories around the world.

Transactions

Action Federal Non-federal Date
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Amendment $537,365 $0
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Amendment $548,904 $0
Amendment $567,551 $0
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Amendment $654,511 $0
Original award $654,511 $654,511
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Subawards

Subrecipient Amount Awarded
The Governors Of The University Of Calgary In order to better understand cryptic diversity in the Aegypti Group in the Southwestern Indian Ocean, we will identify new species using species delimitation… $55,000
Institut De Recherche Pour LE Developpement The IRD will have three primary roles in this proposed program of research. One member of IRD, diego ayala, will be taking a mission (assignment) to be resident… $135,000
Connecticut Agricultural Experimental Station For the proposed project, Dr. Gloria-Soria will be working closely with the Powell lab at Yale, which is located 2 Km from my CAES lab. She has a joint… $20,000
Institut Pasteur De Madagascar The IPM will be the home base for all collecting activities providing logistical support, advice, personnel, and rearing and storage for collections as they… $55,000
Connecticut Agricultural Experimental Station For the proposed project, Dr. Gloria-Soria will be working closely with the Powell lab at Yale, which is located 2 Km from my CAES lab. She has a joint… $104,255

Quick answers

Who received award R01AI155562?

R01AI155562 was awarded to Yale Univ by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on July 6, 2021.

How much is award R01AI155562 worth?

$5,945,465 has been obligated on R01AI155562: $5,267,546 in federal funding and $677,919 in non-federal funding.

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