Project Grant R01AI129835

This Project Grant award of $413,860 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to investigate the interactions between non-tuberculous mycobacteria (NTM) infections, specifically Mycobacterium abscessus (MAB), and the onset/flares of systemic lupus erythematosus (SLE). Using preclinical mouse models and an ex vivo model with alveolar-like macrophages, the researchers will examine the...

This Project Grant award of $405,350.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research aims to characterize lipid droplets in macrophage subsets and determine if manipulating lipid droplet content can shift macrophage function, with the goal of uncovering new therapeutic targets for systemic lupus erythematosus (SLE). The award recipient is The...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is providing $239,348 to The Trustees of Columbia University in the City of New York to investigate the impact of regulatory T cells (Tregs) on host susceptibility to Pseudomonas aeruginosa infection. The key objectives are to evaluate whether Tregs protect against P. aeruginosa pneumonia by altering the airway...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $1,640,492 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Albert Einstein College of Medicine to study the role of the ESX5 secretome of Mycobacterium tuberculosis in TB and TB-HIV pathogenesis and immunity. The researchers generated a genetic deletion of the ESX5 locus, which they found produced a live attenuated vaccine that is highly effective at preventing TB in...

This federal Project Grant award of $743,817 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to delineate T cell receptor (TCR) families associated with protection from progression to pulmonary tuberculosis (TB) disease. The research will use advanced imaging techniques like fluorodeoxyglucose positron emission tomography and computed tomography (FDG PET-CT) to identify TB-exposed household...

This federal Project Grant award of $788,478 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research at the University of Texas Medical Branch at Galveston (UTMB) to investigate the role of C-type lectin receptor (CLR) signaling through the macrophage galactose-type lectin (MGL) in regulating macrophage immune metabolism and the host lipid response during Mycobacterium tuberculosis (MTB) infection. The research aims to 1) identify how...

This Project Grant award of $239,348.00, granted by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), is funding research to investigate a newly identified population of CD1a-restricted T cells that respond to the lipid antigen phosphatidylglycerol (PG). The research aims to determine under what (patho)physiological conditions mitochondrial PG becomes visible to these T cells, including during mitophagy, induction of...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant titled "Role of Tryptophan Catabolism and AHR Pathways in Natural Resistance of Leishmania (Viannia) panamensis to Antimonial Drug" to the University of Maryland, College Park on September 24, 2025. The $193,733 award supports research to investigate the resistance of the Leishmania (Viannia) panamensis parasite, a major cause of cutaneous leishmaniasis in Colombia, to antimonial drugs. The...

This $450,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Arkansas for Medical Sciences (UAMS) aims to enhance the understanding of macrophage subsets in tuberculosis (TB) infection and lesion biology. The project will leverage the C3HeB/FeJ mouse model, which forms the caseous necrotic lesions observed in human TB, to investigate how different lung macrophage subsets influence...

This $227,096 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the University of California, Berkeley to investigate nutrient acquisition strategies utilized by the tuberculosis pathogen Mycobacterium tuberculosis (MTB) during infection of human macrophages. The researchers have developed a novel genetic screening technique called Random Barcode Transposon Site Sequencing (RB-TnSeq) to...