Project Grant R01AI095183

This three-year Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences totals $1,512,792 to fund research at Louisiana State University examining the gene regulatory networks affected by purine catabolites in bacterial pathogens. The research aims to identify additional transcription factors in Burkholderia thailandensis responsive to urate and xanthine, which accumulate in host tissues during infection due to production of reactive oxygen species....

The University of Texas Southwestern Medical Center received a $300,000 Project Grant from the National Institute of General Medical Sciences' Biomedical Research and Research Training program to support research on the biophysical study of endoplasmic reticulum (ER) protein recognition for degradation and lipid homeostasis. The award period is from April 1, 2021 through March 31, 2022. The grant will fund research to elucidate the molecular and biophysical mechanisms underlying the targeted...

Federal Project Grant Award Summary The Sloan-Kettering Institute for Cancer Research received a $609,493 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded June 1, 2025, with a completion date of May 31, 2030. This five-year research initiative will generate fundamental scientific knowledge regarding the protein machinery and molecular mechanisms underlying lipid droplet (LD)...

This Project Grant award from the National Center for Advancing Translational Sciences (NCATS) under CFDA 93.350 will provide $463,150 to The Regents of the University of California, San Francisco (UCSF) to establish proof-of-concept for enzyme replacement therapy (ERT) as a lifesaving treatment for sphingosine phosphate lyase insufficiency syndrome (SPLIS), an ultra-rare and often lethal metabolic disorder. The project aims to demonstrate the efficacy of ERT in preserving kidney function and...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $457,513 to the University of Texas at Arlington (UTA) to investigate the role of the enzyme indoleamine-2,3-dioxygenase 1 (IDO1) and its downstream metabolite kynurenine in regulating cholesterol homeostasis and macrophage function under inflammatory conditions. The 3-year project aims to elucidate the signaling mechanisms...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the Regents of the University of Michigan a $793,098 Project Grant on September 5, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate tirzepatide as a therapeutic treatment for familial partial lipodystrophy (FPLD). The research addresses a critical unmet medical need, as no FDA-approved therapy currently exists for FPLD in the United States. The...

This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) provides $369,297 to San Francisco State University (SFSU) to develop a synthetic transhydrogenation module to enhance the production of valuable chemicals using engineered organisms. The key objectives are to: Elucidate the structural mechanisms underlying the autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism and impacts...

The National Institutes of Health's National Center for Advancing Translational Sciences (NCATS) awarded a $145,636 project grant (CFDA 93.350) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) to evaluate the relationship between thyroid hormone levels and brown adipose tissue activity, transcriptome, and cellular composition in adult humans. The study aims to better understand the interaction between the thyroid axis and brown adipose tissue in the process of thermogenesis and energy...

This three-year $1.28 million project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at Washington State University to develop a quantitative understanding of lipid metabolic network structure, fluxes, and sub-cellular spatial organization in plant seeds. The goal is to elucidate how plants balance oil accumulation with membrane lipid synthesis to optimize seed oil production without affecting membrane properties. The project will...

Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $429,000 Project Grant to the Regents of the University of Michigan on April 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct investigative research examining host defense mechanisms against bacterial pneumonia in lipodystrophy patients. The award, with a completion date of March 31, 2028, supports research evaluating the therapeutic potential of...