Project Grant R01AI093697

Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant totaling $228,420 to The Leland Stanford Junior University, effective August 1, 2025, through July 31, 2030, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This research project investigates the genetic pathways associated with neurodevelopmental outcomes in children exposed to anti-seizure medications (ASMs) in...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $160,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Children's Hospital Medical Center in Cincinnati, Ohio. The grant supports research to investigate the epigenetic mechanisms underlying neurodevelopmental defects in Menke-Hennekam Syndrome, a rare genetic disorder caused by mutations in the EP300 gene. The project aims to (1) identify maturation and...

This $570,362 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is funding research to evaluate the disease-modifying potential of dimethyl fumarate (DMF) for preventing and treating pharmacoresistant epilepsy. The research aims to determine the pharmacokinetic/pharmacodynamic relationship of DMF, demonstrate stable blood and brain levels using an...

This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $421,047 to the University of Toledo to study the interaction between genetic and environmental risk factors for autism and other neurodevelopmental disorders. The key objectives are to investigate how developmental exposure to the pyrethroid pesticide deltamethrin interacts with a genetic mutation in the SHANK3 gene, which is associated with...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $464,750 to the Icahn School of Medicine at Mount Sinai to conduct research on the genetic determinants of transcription factor binding in pooled microglia samples. The research aims to identify Alzheimer's disease-associated genetic variants that affect the binding of key transcription factors in myeloid cells, such as microglia. The 2-year project will involve performing chromatin...

Federal Project Grant Award Summary Seattle Children's Research Institute received a $3.27M project grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded on September 25, 2025, with completion targeted for June 30, 2029. The Supporting Early Receipt of Services for Infants and Children with Genetic Etiology (SERVICE) study evaluates whether newborn whole genome sequencing (N-WGS) enables timely access to federally-supported...

Grant Award Summary Children's Mercy Hospital received a $433,175 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 1, 2025 through June 30, 2027. The award supports the development of a mosaic messenger ribonucleic acid (mRNA) vaccine designed to prevent hand, foot, and mouth disease (HFMD) caused by human enterovirus A viruses. The research deliverables include the design...

Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $220,050 to The Children's Hospital of Philadelphia Research Institute on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This five-year project, extending through July 31, 2030, will advance clinical trial readiness for SYNGAP1-related disorder (SYNGAP1-RD), a rare monogenic epilepsy characterized by...

This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to study the relationship between mitochondrial dysfunction and the impact of non-syndromic autism spectrum disorder (ASD)-related risk genes on neuronal structure and function. The $253,500 award, provided from April 2025 to March 2027, will support the development of...

This federal Project Grant award of $225,599, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research on the contributions of sex chromosomes versus gonadal hormones in shaping sex differences in epilepsy. The University of Illinois, the awardee, will utilize in vivo video-electroencephalography, RNA sequencing, and immunostaining to determine...