Project Grant R01AG101742
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $242,846 to the Icahn School of Medicine at Mount Sinai on August 15, 2025, under the Aging Research program (CFDA 93.866) to develop and validate a novel chest computed tomography (CT)-based frailty screening tool using artificial intelligence-assisted multi-organ body composition analysis. The five-year project, which extends through July 31, 2030, addresses a critical clinical gap in frailty assessment among...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Regents of the University of California, San Francisco $3.43 million under the Aging Research program (CFDA 93.866) for a four-year project (September 15, 2025 – August 31, 2029) investigating biological drivers of sex differences in frontotemporal dementia (FTD). The research leverages two deeply phenotyped, longitudinally-followed cohorts comprising 1,095 participants with genetic and sporadic forms of FTD...
- Federal Project Grant Award Summary Columbia University's Health Sciences Division received a $3.44M Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025 through August 31, 2029. This research initiative investigates the molecular mechanisms and genetic basis of human ovarian aging, addressing a significant gap in women's health research. The project employs advanced genomic sequencing techniques, including...
- Federal Project Grant Award Summary Massachusetts General Hospital received a $269,452 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective February 18, 2026, through November 30, 2028. The grant supports research into the causal mechanisms of proteomic aging and the development of clinical prediction tools for frailty risk. The project integrates large-scale genetic, multi-omic, and clinical data from the UK Biobank, Multi-Ethnic Study of...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Wisconsin–Madison a Project Grant totaling $698,690 under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms underlying age-related skeletal muscle dysfunction. The five-year research initiative, commencing February 1, 2026 and concluding January 31, 2031, will deliver scientific research products focused on understanding how aging differentially affects slow versus fast...
- Federal Grant Award Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded The Washington University a Project Grant of $326,550 effective June 15, 2026, through March 31, 2031. This award funds biomedical research directed toward understanding the neural circuit mechanisms underlying age-related changes in female social behavior, specifically addressing menopause-related depression, social withdrawal, and loss of sexual motivation. The research...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Washington a $651,175 Project Grant on February 1, 2026, under the Aging Research program (CFDA 93.866) to support longitudinal research examining the developmental pathways linking female pubertal timing to long-term health outcomes. The project delivers a second follow-up (FU2) visit for female participants in the landmark National Institute of Child Health and Human Development (NICHD) Study of Early...
- Federal Grant Award Summary The National Institute on Aging awarded the University of Michigan a Project Grant of $298,419 under the Aging Research program (CFDA 93.866) effective February 1, 2026, through January 31, 2031. This award supports the development of novel machine learning and statistical methodologies designed to analyze immune system data and enhance understanding of immunosenescence and aging-related diseases. The project deliverables include four primary aims: (1) a nonparametric...
- Federal Grant Award Summary Fred Hutchinson Cancer Center received a $785,867 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded June 1, 2026, with completion targeted for May 31, 2031. The grant supports epidemiological and mechanistic research examining Clonal Hematopoiesis of Indeterminate Potential (CHIP) in aging and exceptional longevity among older women. The project deliverables include analysis of approximately 10,000 older women from the...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Leland Stanford Junior University a Project Grant totaling $1,468,868 under the Aging Research program (CFDA 93.866), effective January 15, 2026, with a completion date of November 30, 2030. This multi-investigator research initiative seeks to elucidate how the brain functions as a "neural pacemaker" to regulate organismal aging across a complete lifespan. The research leverages the killifish model organism—a...
The National Institute on Aging (NIA) awarded the Institute for Systems Biology a $614,032 Project Grant (CFDA 93.866, Aging Research program) effective July 1, 2026 through June 30, 2031 to conduct research addressing the sex-frailty paradox—the phenomenon wherein women demonstrate higher frailty scores than men at comparable ages yet experience lower mortality rates. The research will deliver three integrated products: (1) benchmarking analysis of commonly used frailty assessment tools across multiple large-scale, global human datasets to identify potential sex bias; (2) identification of sex-specific, modifiable molecular and environmental drivers of frailty through artificial intelligence-powered analysis of multi-omic and exposome data; and (3) mechanistic testing of sex differences in frailty using genetically diverse mouse models (UM-HET3 mice and Four Core Genotype models). Upon completion, this project will produce enhanced understanding of the biological and socio-environmental mechanisms underlying sex differences in frailty, along with precision tools and targeted interventions for detection, prevention, and treatment of frailty applicable to all older adults. The work will be conducted in Seattle, Washington by a research team led by early-career Principal Investigator Kane and supported by experts in sex differences, large-scale clinical data analysis, and systems biology.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $614.0k | 6/18/26 |