Project Grant R01AG100339
- The National Institute on Aging awarded the University of Florida $439,739 on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate biobehavioral signatures of repetitive head impacts at the intersection of aging and Alzheimer's disease. The award funds a longitudinal multi-site study examining fluid biomarkers, neuroimaging, and cognition in aging adults with and without prior repetitive head impacts (RHI). The research addresses how RHI—exposure from contact sports,...
- The National Institute on Aging awarded $191,832 to North Florida Foundation For Research And Education, Inc. on August 15, 2026, under the Aging Research program (CFDA 93.866) to support a K23 career development grant focused on brain aging and Alzheimer's disease risk. The award funds research investigating the relationship between cognition and the autonomic regulatory system in older adults at varying risk for Alzheimer's disease and related dementias. The principal investigator will...
- The National Institute on Aging awarded the University of Florida $182,570 on July 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a prospective cohort study validating diffuse optical tomography (DOT) as a portable neuroimaging biomarker for mapping brain function in delirium and post-delirium Alzheimer's disease and related dementias. The award supports research examining whether DOT can identify impaired cerebral oxygenation and functional dysconnectivity in the...
- The National Institute on Aging awarded the University of South Florida $3,331,541 on September 22, 2025, under the Aging Research program (CFDA 93.866) to conduct transcriptome-wide mapping of brain N6-methyladenosine (m6A) methylome in Alzheimer's disease. The award runs through May 31, 2030, with place of performance in Tampa, Florida. The research will create the first high-resolution reference map of brain m6A methylome in older adults using novel base-resolution quantitative m6A...
- The National Institute on Aging awarded the University of Florida $5.551 million on July 1, 2026, under the Aging Research program (CFDA 93.866) to identify neural signatures that distinguish early Alzheimer's disease from normal aging. The recipient will record electrical activity from ten brain regions across the lifespan in human tauopathy mouse models (HTAU mice) and wild-type controls (C57BL/6J), computing new electrical oscillatory features called electome factors to distinguish between...
- The National Institute on Aging awarded the University of Miami $3.73 million on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and internally validate predictive markers and a composite risk score for phenoconversion to clinically manifest amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD) in C9ORF72 repeat expansion carriers. The award funds evaluation of leading clinical markers and biomarkers—including presence of prodromal syndrome, thalamic...
- The National Institute on Aging awarded the University of Colorado-Denver $429,000 under the Aging Research program (CFDA 93.866) on September 1, 2026, to develop clinical decision support tools and implementation guidance for primary care clinicians and patients navigating Alzheimer's disease blood biomarker testing and diagnostic decision-making. The project, R21AG104791, addresses a gap in primary care capacity to diagnose Alzheimer's disease and incorporate newly FDA-approved blood...
- The National Institute on Aging awarded North Carolina Central University $673,720 on September 4, 2026, under the Aging Research program (CFDA 93.866) to develop fluid biomarkers for diagnosing limbic-predominant age-related TDP-43 encephalopathy (LATE) and differentiating LATE from Alzheimer's disease dementia. The project will develop TDP-43 seed amplification assay and tau-SAA as diagnostic tests for LATE, characterize the effects of co-existing TDP-43 pathology on tau pathology across...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Boston University Medical Campus $4.27 million under the Aging Research program (CFDA 93.866) for a two-year project period (June 1, 2025 – May 31, 2027) to advance research on the long-term health consequences of repetitive head impacts (RHI) across the lifespan. This project extends the work of the UNITE Brain Bank, the world's largest RHI and chronic traumatic encephalopathy (CTE) tissue repository currently...
- The National Institute on Aging awarded Rush University Medical Center $656,503 under CFDA 93.866 (Aging Research) on September 1, 2026, to develop and validate an in-vivo MRI-based classifier for detecting cerebral amyloid angiopathy in community-dwelling older adults. The project combines multimodal MRI imaging with neuropathological data to create a machine-learning classifier capable of identifying cerebral amyloid angiopathy—a common age-related pathology affecting up to 80 percent of older...
The National Institute on Aging awarded the University of Florida $788,481 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop clinical diagnostic tools for chronic traumatic encephalopathy (CTE) during life, distinguishing CTE from Alzheimer's disease and related dementias. The research will apply automated imaging differentiation of dementia (AIDD), a novel disease classification method, to brain imaging data. Blood-based biomarkers (NulisaSeq) will complement imaging findings by measuring altered inflammation and immune-signaling pathways correlated to brain pathology. Magnetoencephalography (MEG) will characterize functional brain networks disrupted in CTE and their association with cognitive and neurobehavioral symptoms. The work leverages data from three Alzheimer's Disease Research Centers located in Florida, Boston University, and UCSF, and the Diagnose-CTE research project. The project runs through May 31, 2031, with place of performance in Gainesville, Florida. This R01 award to an early-stage investigator develops three specific aims: diffusion-based MRI programming for automated CTE detection, blood-based protein biomarkers for disease differentiation, and MEG-based functional brain network characterization. Study groups include suspected and autopsy-confirmed CTE cases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $788.5k | 8/26/26 |