Project Grant R01AG100193
- The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $761,496 on June 15, 2026, to investigate epigenetic mechanisms linking delirium and cognitive decline under the Aging Research program (CFDA 93.866). The recipient will test the hypothesis that epigenetic risk, measured by DNA methylation, identifies individuals with a vulnerable brain predisposed to delirium, cognitive decline, and Alzheimer's disease and Alzheimer's disease-related dementias in the setting of...
- The National Institute of Environmental Health Sciences awarded The Feinstein Institutes For Medical Research $139,836 on July 1, 2026, under the Medical Library Assistance program (CFDA 93.879) to develop and disseminate AI-driven software tools for early prediction of clinical deterioration in hospitalized patients. The recipient will fund a research software engineer to develop next-generation personalized deterioration prediction models using clinical wearable data and generative...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded Weill Medical College of Cornell University $172,260 on July 1, 2026, under the Aging Research program (CFDA 93.866) to characterize the relationship between electroencephalographic burst-suppression and postoperative delirium in the context of corticothalamic function. The recipient will investigate biomarkers for postoperative delirium, a neurocognitive disturbance...
- The National Institute on Aging awarded Yale University $839,400 under the Aging Research program (CFDA 93.866) on September 1, 2026, to validate novel algorithms for assessing sleep deficiency in persons with Alzheimer's disease and related dementias. The project addresses the urgent need for feasible, accurate assessment methods for sleep deficiency in ADRD populations, where over half of patients experience sleep abnormalities that accelerate cognitive and functional decline. Existing...
- This $162,745 Project Grant from the National Institutes of Health's National Institute on Aging will support research to improve identification of delirium. Specifically, the grantee will determine the four most commonly used and well-validated delirium identification instruments. They will then harmonize these instruments to generate an item bank and identify optimal cut-points to determine whether a patient has delirium. This work aims to create a unified approach to delirium identification...
- The National Institute on Aging awarded $1,519,197 to Healthy Design LTD. CO. on September 22, 2025, under the Aging Research program (CFDA 93.866) to develop a novel continuous predictive wearable agitation monitor using actigraphy and artificial intelligence for hospitalized older adults to prevent delirium and dementia. The device delivers real-time monitoring and alerting to detect agitation in confused patients at risk for equipment dislodgement, replacing the current standard of...
- The National Institute on Aging awarded the University of California, Berkeley $549,260 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop advanced large language model-based AI tools that enhance precision in predicting Alzheimer's disease pathology and cognitive outcomes. The research addresses critical gaps in precision medicine for Alzheimer's disease, particularly the need to capture patient heterogeneity, accurately identify treatment candidates for...
- The National Institute on Aging awarded Rush University Medical Center $656,503 under CFDA 93.866 (Aging Research) on September 1, 2026, to develop and validate an in-vivo MRI-based classifier for detecting cerebral amyloid angiopathy in community-dwelling older adults. The project combines multimodal MRI imaging with neuropathological data to create a machine-learning classifier capable of identifying cerebral amyloid angiopathy—a common age-related pathology affecting up to 80 percent of older...
- The National Institute on Aging awarded The Feinstein Institutes For Medical Research $460,625 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the mechanistic underpinnings of electrical trigeminal nerve stimulation for enhancing neuropsychological function in dementia. The project addresses neuropsychiatric symptoms—including anxiety and depression—that affect up to 80 percent of dementia patients and significantly contribute to cognitive decline and...
- The National Institute on Aging awarded Education Development Center, Inc. $320,150 under the Aging Research program (CFDA 93.866) on September 1, 2026. The research project examines elder mistreatment and self-neglect among older adults with Alzheimer's disease and related dementias, leveraging the UCLA Alzheimer's and Dementia Care (ADC) Program's longitudinal dataset of structured data and clinical notes from dementia care specialists. The study expands the existing dataset to include three...
The National Institute on Aging awarded The Feinstein Institutes For Medical Research $698,456 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop machine learning models that identify and predict delirium in hospitalized older adults. The project addresses two clinical gaps: the high rate of missed delirium diagnoses in emergency departments (over 75% missed despite intensive screening) and the need to identify high-risk patients during hospital admission to enable timely prevention strategies. The recipient will develop and validate machine learning methods using two existing curated datasets with structured and unstructured electronic health record data to identify patients with emergency department delirium and predict imminent risk of delirium development during hospitalization. The project leverages prospective validation and a reference standard delirium assessment applied to a large, heterogeneous population. Performance occurs in Manhasset, New York, with a period of performance from September 1, 2026, through May 31, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $698.5k | 8/25/26 |