Project Grant R01AG096604
- The National Institute on Aging awarded New York University School of Medicine $3,557,115 on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate the neurobiological mechanisms linking menopause and cognitive decline in women. The recipient will conduct a longitudinal study mapping neurobiological changes during the menopause transition in a cohort of 120 pre- and perimenopausal women aged 40–48 using state-of-the-art neuroimaging, plasma proteomics, and clinical...
- The National Institute on Aging awarded Northwestern University $198,164 on September 27, 2025, under the Aging Research program (CFDA 93.866) to investigate sex-specific hypothalamic pathology and immune infiltration in Alzheimer's disease. The project, designated F31AG091984, runs through May 31, 2028, with work performed in Chicago, Illinois. The research addresses sex disparities in Alzheimer's disease prevalence—nearly two-thirds of cases occur in females—by examining mechanisms of immune...
- The National Institute on Aging awarded the University of California, Santa Barbara $200,918 on March 18, 2026, under the Aging Research program (CFDA 93.866) to conduct research establishing the role of ovarian hormones in spatial navigation as an early diagnostic target for Alzheimer's disease. The research investigates associations between ovarian hormones and navigation ability in women across two critical timeframes: menstrual cycle phase-level fluctuations and longer-term endocrine aging...
- The National Institute on Aging awarded Georgetown University $156,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate mitigation strategies for network dysfunction in Alzheimer's disease pathology. The project tests whether mild hyperpolarization can stabilize hippocampal network activity despite amyloid-beta-related impairment of excitatory amino acid transporters. The research quantifies sharp wave-ripples in ex vivo hippocampal slices from 5XFAD transgenic...
- The National Institute on Aging awarded the University of Florida Division of Sponsored Research $618,412 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms of menopause-induced coronary microvascular disease and develop novel therapies. The research project, titled "Menopause Transition and Coronary Microvascular Disease," examines how hormonal imbalance during menopause increases cardiovascular disease risk in women,...
- The National Institute on Aging awarded The Washington University $326,550 on June 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the neural circuit basis of age-related changes in female sexual behavior during reproductive aging. The project, led through Washington University's Office of Sponsored Research Services in St. Louis, Missouri, will define how hormonal decline during menopause disrupts hormone-sensitive neural circuits and impairs female sexual behavior....
- The National Institute on Aging awarded the University of Southern California $149,190 on August 6, 2026, under the Aging Research program (CFDA 93.866) to investigate how early-stage Alzheimer's disease disrupts coordinated release dynamics between acetylcholine and norepinephrine in the cortex and how this discoordination impairs cognitive performance. The research characterizes the evolution of coordinated cortical acetylcholine and norepinephrine release activity in vivo in wildtype mice,...
- The National Institute on Aging awarded The General Hospital Corporation, doing business as Massachusetts General Hospital, $3,558,232 under the Aging Research program (CFDA 93.866) on August 5, 2026, to conduct the WHIMSY-AD Study examining menopause and related midlife risk factors and their impact on later-life Alzheimer's disease pathology and cognition. The study recontacts 700 participants from the Women's Health Initiative Memory Study of Younger Women (WHIMSY), now aged 75–84 years,...
- The National Institute on Aging awarded The Regents of the University of California, San Francisco $902,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the steroid hormone androst-5-ene-3β,17β-diol (ADIOL) as a regulator of cognitive resilience and protection against age-related cognitive decline and Alzheimer's disease. The project conducts mechanistic studies in mice and correlative studies in humans to test the hypothesis that ADIOL, acting through...
- The National Institute on Aging awarded The Johns Hopkins University $653,100 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate poly(ADP-ribose) polymerase 1 (PARP1) and macrophage migration inhibitory factor (MIF) nuclease activity in tau-related neurodegeneration and cognitive dysfunction. The research will examine neurobehavior and neuropathology in PS19 transgenic mice models with PARP1 knockout and MIF nuclease-deficient or tautomerase-deficient genetic...
The National Institute on Aging awarded Rosalind Franklin University of Medicine & Science $696,253 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how hormonal fluctuations during perimenopause alter hippocampal neural circuits and accelerate Alzheimer's disease pathology in female mice. The recipient will use 4-vinylcyclohexene diepoxide (VCD) to chemically induce ovarian failure in AppNLGF knock-in AD model mice, mimicking human perimenopause transition. Research will examine how perimenopause disrupts hippocampal cell types and neural activity patterns, focusing on dorsal and ventral hippocampal regions implicated in anxiety-like behaviors and memory decline observed in female AD mice during this transition. The work will measure neuronal ensemble activation, parvalbumin-positive inhibitory neuron activity, and behavioral outcomes including anxiety and fear memory to determine whether perimenopause accelerates AD-related neural and behavioral phenotypes. Performance occurs in North Chicago, Illinois, with a period of performance from September 1, 2026, through May 31, 2031. This is a Project Grant, the standard assistance type for NIH research awards.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $696.3k | 8/28/26 |