Project Grant R01AG096154
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging awarded the Buck Institute for Research on Aging $809,486 for Project Grant R01AG095381 on February 1, 2026, under the Aging Research program (CFDA 93.866). The award funds investigation of the role of OXR1 (oxidation resistance 1) and retromer proteins in brain aging and Alzheimer's disease and related dementias. The research exploits dietary restriction as an intervention to slow aging and neurodegeneration, using fruit fly and human-induced pluripotent stem...
- The National Institute of Child Health and Human Development awarded the Buck Institute for Research on Aging $194,000 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate ovarian aging through the three-dimensional lymphatic network. The research examines how the lymphatic vasculature contributes to ovarian function across adulthood and aging, with focus on three-dimensional lymphatic structure and function and...
- The National Institute on Aging awarded The Scintillon Institute $501,160 on May 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate genetically encoded tools that modulate redox metabolism in tissue- and compartment-specific manner to study aging in Drosophila models. The award funds development of novel tools to directly manipulate NADH/NAD+ and NADPH/NADP+ ratios when expressed in different tissues and cellular compartments. The research tests the hypothesis that...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Trustees of Columbia University in the City of New York $149,190 on August 6, 2026, under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms by which NBR2, a long non-coding RNA, contributes to ovarian aging. The research addresses female-specific health conditions through genome-wide association studies and functional genomic studies in human ovarian cell models. The...
- The National Institute on Aging awarded Northwestern University $400,000 on June 15, 2026, under the Aging Research program (CFDA 93.866) to investigate dysregulated ovulatory debris clearance as a driver of ovarian fibroinflammaging. The research examines age-related failure in the ovary's mechanisms to remove cellular debris accumulated through follicular growth, ovulatory rupture, and corpus luteum regression, and tests whether enhancing debris clearance mechanisms can improve ovarian...
- The National Institute on Aging awarded $648,930 to the Regents of the University of California, doing business as University of California, Berkeley, on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop human stem cell-based microphysiological systems for aging research. The recipient will create a novel human aging-on-a-chip platform integrating fat and liver tissues derived from human induced pluripotent stem cells (hiPSCs) and microfluidics using serum from young...
- The National Institute on Aging awarded the University of Pittsburgh $453,785 on May 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cross-species roles of TCER-1/TCERG1 in fertility and reproductive aging. The project examines whether the mammalian transcription elongation and splicing factor TCERG1 functionally conserves the C. elegans protein TCER-1, which regulates the fertility-immunity-longevity axis. Preliminary data show that worm and mammalian TCERG1 both regulate...
- The National Institute on Aging, within the Department of Health and Human Services, awarded Trustees of Boston University $343,350 on May 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the contribution of genes repressed by endogenous double-stranded RNA-derived small RNAs to lifespan extension. The research focuses on major sperm protein genes repressed by small RNAs and argonaute proteins expressed in the spermatogenic germline, building on prior findings that high...
- The National Institute on Aging awarded $580,636 to North Carolina State University on January 15, 2026, under the Aging Research program (CFDA 93.866) to develop BOWID, a barcode system for lifelong tracking of individual Caenorhabditis elegans nematodes in aging studies. The project addresses a critical limitation in current aging research: population-level survival analysis obscures individual animal identity and prevents tracking of how early-life events shape aging trajectories and...
The National Institute on Aging awarded the Buck Institute for Research on Aging $821,486 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate how diet and reproductive status interact to influence ovarian aging and systemic healthspan in fruit flies and humans. The research integrates large-scale human population datasets with mechanistic studies in Drosophila melanogaster. In the first aim, the recipient will leverage human datasets and plasma proteomics to define molecular signatures of ovarian and systemic aging, construct a proteomic "ovarian aging clock," and assess causal relationships between reproductive timing and age-related outcomes using Mendelian randomization approaches. In the second aim, the recipient will employ Drosophila models to dissect how reproductive effort and dietary restriction modulate aging pathways. The work tests the hypothesis that early childbirth in humans or mating in flies accelerates both reproductive and systemic aging in an evolutionarily conserved manner, and that dietary restriction can modulate these aging effects by reprogramming metabolic and transcriptional pathways. Performance occurs in Novato, California, with work extending through July 31, 2031. The award is assistance type Project Grant and represents one year of funding within the five-year project period.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $821.5k | 8/18/26 |