Project Grant R01AG093112
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded $633,393 in Project Grant funding to the Palo Alto Veterans Institute for Research (Pavir) beginning January 1, 2026, and extending through December 31, 2030, under the Aging Research program (CFDA 93.866). The award supports research investigating the dysregulated metabolic-matrix axis in metabolic dysfunction-associated steatohepatitis (MASH) and hepatocellular carcinoma (HCC), with particular focus on age-related...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $398,046 Project Grant to the Palo Alto Veterans Institute for Research (PAVIR) effective September 5, 2025, through August 31, 2027, under the Aging Research program (CFDA 93.866). The award funds a research initiative investigating the combined efficacy of anti-amyloid monoclonal antibody therapy and repetitive transcranial magnetic stimulation (rTMS) for treating mild cognitive impairment (MCI) and Alzheimer's...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $1,459,072 on August 1, 2025, under the Aging Research program (CFDA 93.866) to conduct research on Alzheimer's Disease (AD)-related neurological dysfunction. The research will deliver scientific knowledge and methodological innovations focused on understanding how inhibitory interneurons—specifically parvalbumin (PVALB) and somatostatin (SST) cell types—contribute...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $152,300 under the Aging Research program (CFDA 93.866) to The Salk Institute for Biological Studies for the period August 6, 2026 through August 5, 2027. This F32 fellowship grant supports research investigating how disease tolerance mechanisms—physiological defenses that protect against infection-related damage without reducing pathogen burden—are altered during the aging process. The research...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $2,809,832 in Project Grant funding to the University of Pennsylvania, effective February 1, 2026 through January 31, 2031, under the Aging Research program (CFDA 93.866). This research initiative investigates the epigenetics of aging and age-associated diseases, with primary focus on two interconnected mechanisms: chromostasis (the homeostatic mechanisms that maintain chromatin stability) and regulation of the...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Leland Stanford Junior University a Project Grant totaling $1,468,868 under the Aging Research program (CFDA 93.866), effective January 15, 2026, with a completion date of November 30, 2030. This multi-investigator research initiative seeks to elucidate how the brain functions as a "neural pacemaker" to regulate organismal aging across a complete lifespan. The research leverages the killifish model organism—a...
- Federal Grant Award Summary Virscio, Inc. received a $291,913 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 20, 2025, with completion targeted for September 19, 2026. The grant supports the development of epigenetic and senescent cell biomarkers derived from nonhuman primate (NHP) tissues to advance aging science and anti-aging therapeutic strategies. Specifically, Virscio will develop biomarker tools based on DNA...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Salk Institute for Biological Studies a Project Grant of $620,441 effective February 15, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This research initiative investigates activity-dependent cell survival mechanisms in the adult somatosensory dorsal horn and the functional consequences of neuronal remodeling during aging. The project applies advanced transcriptomic and...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Van Andel Research Institute (VAI) $528,000 in project grant funding (CFDA 93.866, Aging Research program) effective September 15, 2025, with a completion date of August 31, 2027. The award supports the development and application of advanced single-cell whole-genome bisulfite sequencing technology combined with lineage tracing methodologies to analyze epigenetic clocks at the single-cell level. The research aims...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital (MGH) a Project Grant of $463,000 under the Aging Research program (CFDA 93.866) on May 1, 2026, with a completion date of January 31, 2031. This grant supports research directed toward understanding chromatin mechanisms associated with cytoplasmic chromatin fragments (CCF) during cellular senescence and aging. The research addresses a critical gap in biomedical science by investigating the...
The National Institute on Aging (NIA) awarded $542,730 to the Palo Alto Veterans Institute For Research (Pavir) under the Aging Research program (CFDA 93.866) for a project titled "Chromatin Signaling Mechanisms in Metabolic Aging and Disease." The award, issued June 15, 2026, with completion targeted for April 30, 2031, supports fundamental biomedical research investigating how histone deacetylase enzyme SIRT7 regulates chromatin and contributes to aging-related metabolic pathologies. The research employs biochemical, cellular, and genomic approaches utilizing SIRT7 knockout and overexpression mouse models to examine protective mechanisms against aging and metabolic disease, with particular focus on a novel histone substrate (H3K36) and its role in aging and metabolic pathways. This project delivers scientific knowledge and research findings advancing understanding of chromatin regulatory mechanisms that become dysregulated in aging and associated metabolic conditions such as fatty liver disease, cardiac disease, and hematopoietic dysfunction. The research outcomes will contribute to the NIA's mission of supporting biomedical research directed toward understanding the aging process and age-related diseases through the generation of therapeutic targets, mechanistic insights, and evidence-based knowledge regarding histone modification and chromatin regulation in the context of aging and metabolic health.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $542.7k | 6/9/26 |