Project Grant R01AG092825
- The National Institute on Aging awarded $633,393 to Palo Alto Veterans Institute For Research on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate dysregulated metabolic-matrix pathways in metabolic dysfunction-associated steatohepatitis (MASH) and hepatocellular carcinoma (HCC) in aging populations. The research examines how SRC homology 2 domain containing collagen-related (SHC) adaptor proteins, which increase during aging in the liver, create conditions...
- The National Institute on Aging awarded the University of California, San Diego $140,589 on March 17, 2026, under the Aging Research program (CFDA 93.866) to support research dissecting the molecular mechanism of ketogenic metabolites in Alzheimer's disease. The award funds the F99 phase of a project investigating how beta-hydroxybutyrate (BHB), the primary ketone body produced by ketogenic diets, ameliorates Alzheimer's disease pathology through two mechanisms: metabolic energy production and...
- The National Institute on Aging awarded the Palo Alto Veterans Institute For Research $542,730 on June 15, 2026, under the Aging Research program (CFDA 93.866) to investigate chromatin signaling mechanisms in metabolic aging and disease, with focus on the sirtuin protein SIRT7. The research employs biochemical, cellular, and genomic approaches to understand how SIRT7-dependent histone deacetylation regulates chromatin in aging-associated metabolic pathologies. The project uses SIRT7 knockout...
- The National Institute on Aging awarded the University of Alabama at Birmingham $819,500 on June 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a double-blind pilot randomized clinical trial testing the safety and feasibility of a 10-day oral ketogenic diet in hospitalized older adults with bacterial community-acquired pneumonia. The study, titled the Ketogenic Approach to Restore Muscle in Older Patients with Community-Acquired Pneumonia (KARMA-P) Trial, will enroll 30...
- The National Institute on Aging (NIA) awarded a $442,750 Project Grant (CFDA 93.866) to Duke University to conduct research on using heterochronic (age-mismatched) hepatocyte transplantation to rejuvenate the aged liver. The research aims to understand how transplanting young hepatocytes into old livers, and vice versa, can influence liver function, cellular composition, and the plasma proteome. Key objectives include measuring changes in liver function markers, analyzing the liver's cellular...
- The National Institute on Aging awarded The Leland Stanford Junior University $658,147 for Project Grant R01AG096626 on September 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research into mechanisms of skeletal muscle maintenance relevant to Alzheimer's disease and Alzheimer's disease-related dementia. The research examines how mitochondrial dysfunction, particularly reverse electron transport along mitochondrial complex I, contributes to NAD+ depletion during aging....
- The National Institute on Aging awarded the University of Oklahoma Health Sciences Center $214,500 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate alpha-ketoglutarate as a therapeutic intervention to improve neurogliovascular coupling and cognitive function in older adults. The project will evaluate whether dietary alpha-ketoglutarate supplementation can restore the impaired blood-flow-to-brain-activity coupling mechanism that declines with age, specifically...
- The National Institute on Aging awarded the University of Pittsburgh $664,619 on January 1, 2026, under the Aging Research program (CFDA 93.866) to develop multiscale computational and experimental models of neurometabolic coupling across age-related cognitive decline and late-onset Alzheimer's disease. The research integrates in vivo two-photon microscopy, multispectral wide-field imaging, and magnetic resonance imaging to characterize the relationship between neuronal activity and metabolic...
- The National Institute on Aging awarded Vanderbilt University $482,800 on February 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on sphingolipid-dependent remodeling of mitochondria in aging cells through the project grant R01AG092718. The project investigates how accumulation of sphingolipids contributes to mitochondrial dysfunction during aging and tests whether targeting lipid transfer activities at inter-organelle junctions could promote longevity and...
- The National Institute on Aging awarded The Leland Stanford Junior University $125,766 on July 1, 2026, under the Aging Research program (CFDA 93.866) to identify molecular mediators linking cardiometabolic risk factors to Alzheimer's disease. The research identifies plasma protein and metabolite mediators of cardiometabolic pathways that contribute to Alzheimer's disease risk using large-scale omics data from the UK Biobank and Million Veteran Program. The project comprises three specific aims:...
The National Institute on Aging awarded Palo Alto Veterans Institute For Research a $596,400 Project Grant (CFDA 93.866, Aging Research) on August 1, 2026, to investigate the impact of age on ketogenesis and the liver-gut axis in metabolic disease. The research examines mechanistic factors underlying liver-gut cross-talk in aging, including the role of meta-inflammation, mitochondrial dysfunction, and ketogenesis in young versus old age groups. The recipient will focus on SHC protein modulation to increase ketogenesis and assess resulting improvements in liver and gut outcomes through multiple aims: evaluating SHC deletion effects in the liver and ketone body (beta-hydroxybutyrate) production and downstream effects on macrophage immunophenotype, enteric neuron structure, gastrointestinal motility, and intestinal permeability; exploring how beta-hydroxybutyrate reverses age-dependent changes in gut immunometabolism through FOXO3 signaling to preserve gastrointestinal and liver function in older age; and additional mechanistic studies to be conducted through the project period. Work will be performed in Palo Alto, California, with a period of performance from August 1, 2026, through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $596.4k | 7/20/26 |