Project Grant R01AG092725
- This Project Grant award of $1,602,696.00 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to The Johns Hopkins University. The award is intended to support research investigating the effects of obesity on neurovascular and lymphatic function in the brain, and how these changes may contribute to cognitive impairment. The research will utilize newly developed magnetic resonance imaging (MRI) techniques to assess neurovascular, lymphatic, neuroinflammation, and...
- The National Institute on Aging (NIA) awarded a $333,125 Project Grant under the Aging Research (CFDA 93.866) federal grant program to George Washington University. The grant, which runs from September 17, 2024 to August 31, 2025, will fund the development and validation of artificial intelligence algorithms to predict body composition and physical function in older adults using low-cost 3D optical body scanning technology. The research aims to provide accessible and scalable methods to assess...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), provides $2,679,434 to Ridgeline Therapeutics LLC to conduct preclinical validation of a novel small molecule drug, RT-002, as an adjunct therapy to prevent muscle loss and enhance weight loss in older adults. The research aims to address concerns with existing obesity treatments, such as excessive lean mass loss and weight regain, which disproportionately impact...
- This $2,586,818 Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), supports research conducted by the Fred Hutchinson Cancer Center in Seattle, WA. The research aims to elucidate the mechanisms of communication between adipocytes (fat cells) and the brain, and how these signaling pathways impact glial cell function, neuroprotection, and brain aging. Specifically, the researchers will investigate the roles of...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a study to evaluate the association between lifecourse obesity and Alzheimer's disease and related dementias (ADRD), as well as cognitive decline, in a diverse cohort of Kaiser Permanente members. The $126,750 award will leverage data from three ongoing cohort studies (KHANDLE, STAR, and LA90) to address biases that have impacted findings from previous observational studies on this topic....
- This $2,366,213 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund the INLIFE (Individualized Lifestyle Change for Every Aging Brain) study. The study aims to harmonize and analyze participant-level data from 12 U.S. randomized controlled trials to examine how changes in lifestyle behaviors such as physical activity, cognitive activity, diet, and social engagement impact cognitive outcomes across diverse older adult populations....
- This Project Grant award of $354,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Panorama Research Incorporated supports the development of a novel therapy for sarcopenia, a condition characterized by loss of skeletal muscle mass, quality, and strength commonly seen in aging populations. The research aims to generate longer-lived versions of the adipokine Isthmin 1 (ISM1) and evaluate their ability to promote protein synthesis and suppress protein degradation in...
- This $7,381,140 federal Project Grant awarded by the National Institute of Nursing Research (CFDA 93.361 Nursing Research) on September 11, 2025 will fund a randomized controlled trial to evaluate the effectiveness of providing food support (food vouchers or home-delivered groceries) in addition to behavioral weight loss (BWL) treatment for improving obesity outcomes among 300 adults with food insecurity. The primary objectives are to assess whether the food support interventions (BWL+Voucher...
- This federal Project Grant award of $2,358,537.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults" at the University of Pittsburgh. The project aims to investigate the impact of exercise on epigenetic aging and its relationship to cognitive function, brain health, and Alzheimer's disease biomarkers in non-cognitively impaired older adults. The award period runs from...
- This $6,448,430 Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) is focused on identifying multi-scale mechanisms for the age-related increase in the metabolic cost of walking. The central hypothesis is that older adults select slower gait speeds to prioritize stability over economy, and these "safer", proximally-biased gaits combine with declines in neuromuscular efficiency to elevate the metabolic cost of...
This federal Project Grant award in the amount of $749,481 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to the Pennington Biomedical Research Center in Baton Rouge, Louisiana. The funding will support a 12-week randomized controlled trial to test the hypothesis that a low-energy density diet combined with exercise can reduce fat mass, improve muscle function, and increase energy deficit in 80 older adults with obesity and insulin resistance. The study aims to determine the effects of this lifestyle intervention on metabolic outcomes, providing critical insights to preserve musculoskeletal health and cognitive benefits of weight loss in the older adult population. The award has a start date of January 1, 2026 and a completion date of December 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $749.5k | 12/24/25 |