This $4,444,978 federal Project Grant award, issued by the National Institute on Aging (CFDA 93.866 Aging Research program), supports research to characterize cognitive reserve and identify modifiable factors that promote cognitive reserve and resilience to Alzheimer's disease and related dementias (ADRD) among older adults in India, with a focus on those who lack formal education. The project aims to: 1) compare brain pathology measures and their contributions to cognition between older...
This $2,365,042 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to conduct research on the biological underpinnings of Alzheimer's disease and related dementias (ADRD). The research aims to better characterize the interplay between biological markers of neurodegeneration, vascular, nutritional, and inflammatory systems, and their interface with social and economic factors, by leveraging cross-national comparisons...
This $223,902 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a feasibility study to establish data collection protocols and harmonize genetic and phenotypic data from a consanguineous population in Pakistan for inclusion in the Alzheimer's Disease Sequencing Project (ADSP). The key products and services to be delivered under this award include: Harmonizing data acquisition protocols with the Longitudinal Aging Study in India - Diagnostic...
This $2,288,528 federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to improve cross-national measurement of mild cognitive impairment (MCI) and characterize its longitudinal course across diverse populations in the U.S., Mexico, and India. The study will harmonize MCI and dementia diagnoses, compare MCI prognosis, and investigate sociodemographic, lifestyle, health, and biological risk factors associated with MCI and dementia across...
The National Institute on Aging (NIA) awarded a Project Grant (CFDA 93.866 - Aging Research) in the amount of $661,016 to the University of Southern California (USC) to develop a "Federated Deep Learning to Accelerate Alzheimer's Disease Research" project. The key products and services to be delivered include: Establishing an international "Federate AD" alliance to leverage innovative AI techniques and distributed computation to study Alzheimer's disease (AD) across large,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support Emory University's research into the genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias. The $528,876 award, effective June 1, 2025, will fund the development of new analytic tools to integrate genomic data across multiple tissues and improve the identification of genetic risk factors and underlying molecular mechanisms for...
This Project Grant award of $840,931 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), aims to characterize family structure, care utilization, and well-being among persons with Alzheimer's disease and related dementias (ADRD) in the Asian region. The research will leverage data from 10 national aging studies in Asia to (1) identify major types of family structures providing dementia caregiving, (2) assess factors associated with these family structures,...
This $1,505,109 Project Grant awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to identify undiagnosed Alzheimer's disease (AD) in non-Hispanic White, Hispanic/Latino, and non-Hispanic African American populations. The project will leverage electronic health records and genetic data to develop disease trajectory models and polygenic risk scores to detect undiagnosed AD, while addressing the issue of underdiagnosis in underserved...
This $839,262 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a multilevel investigation into the effects of migration on the risk of Alzheimer's disease and related dementias (ADRD) among Mexican Americans. Conducted by the Trustees of Columbia University, the study will leverage a unique binational dataset to (1) estimate the impact of migration, US residence, and acculturation on cognitive function and dementia risk, (2) evaluate how...
This Project Grant award of $2,557,260.00 from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) will support a longitudinal study to investigate the transition from midlife to early late-life and the development of early clinical Alzheimer's disease and related dementias (AD/ADRD) among diverse populations. The study, led by the University of California, San Francisco, will conduct cognitive assessments and AD/ADRD adjudication on participants in the...
This $12,847,914 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) is supporting a comprehensive study titled "P-CARRS-BRAIN: Multi-Domain (Genetic, Socio-Behavioral, Vascular) Risk Factors and Prediction of Alzheimer's Disease Continuum in South Asians in India." The award is being led by Emory University and leverages the NHLBI-funded Precision-CARRS cohort to investigate preclinical Alzheimer's disease and related dementias in middle-aged South Asians. Key activities include multimodal phenotyping, genetic characterization, and analysis of modifiable risk factors to develop predictive models for early detection. The project also involves sub-awards to the Madras Diabetes Research Foundation, National Institute of Mental Health and Neuro Sciences, and Centre for Chronic Disease Control in India to support data collection, biomarker analysis, and other research activities. This study aims to advance understanding of the natural history of Alzheimer's disease and enable earlier intervention strategies for this high-risk population.