Project Grant R01AG089700

Award Date 6/1/25
Completion Date 2/28/30
Dollars Obligated $730K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Missouri, USA
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Specific aims include: 1) determining the ability of digital markers of social isolation and life space to distinguish between cognitively normal older adults with and without preclinical AD, 2) modeling longitudinal trajectories of driving behavior and physical activity to assess life space constriction and social isolation over time, and 3) exploring the effects of social determinants of health factors, including air pollution, neighborhood characteristics, and cognitive stimulation, on social isolation and life space. The study will leverage existing institutional infrastructure to longitudinally follow 500 cognitively normal older adults across two geographically distinct sites in St. Louis, Missouri and Greenville, South Carolina.

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