This $6,226,692 project grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support research to examine the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the development of Alzheimer's disease (AD). The primary focus is on investigating how modifications in brain activity, particularly in the locus coeruleus (LC) and hippocampus (HPC) regions, can lead to the key pathological hallmarks of AD....
The National Institute on Aging (NIA), part of the Department of Health and Human Services National Institutes of Health, awarded a $3.37 million Project Grant to The University of Texas at Arlington to develop an individualized deep connectome framework for Alzheimer's disease and related dementias (ADRD) analysis. The three-year grant, awarded on August 18, 2022 under the NIA's Aging Research program (CFDA 93.866), will support research to discover and identify individualized...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $203,278 to Brandeis University from November 2024 to January 2026 to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The project will use a multilevel, multimodal framework including behavioral, psychophysiological, neuroimaging, and naturalistic approaches to understand...
This Project Grant award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, provides $715,801 to Duke University to investigate the causal role of blood-brain barrier dysfunction and neuroinflammation in exacerbating postoperative delirium and subsequent onset of Alzheimer's disease and related dementias in aging and hypertension. The overarching goal is to elucidate how hypertension primes the neurovascular unit and worsens delirium-like behavior after orthopedic...
The National Institute on Aging (NIA) awarded a $137,895 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of California, Berkeley (UC Berkeley) with a project period from December 3, 2024 to July 31, 2027. The grant will fund a study to investigate how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. Specifically, the project will use positron emission tomography (PET)...
This Project Grant award of $372,690 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to discover the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The project will develop new statistical methods to uncover how amyloid-beta, tau accumulation, and cognition are causally related in different AD subpopulations. The goal is to reveal optimal treatment windows and target groups for therapies that reduce amyloid-beta or...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $423,500 to The Leland Stanford Junior University to conduct research on the neurobiological mechanisms underlying attention and memory processes, and how they are altered in human aging. The 2-year project will examine behavioral, electrophysiological, and pupillometry-based rhythms of feature-based attention and episodic memory encoding in a well-powered sample of 150 young and cognitively...
The National Institute on Aging (NIA) awarded a $2,168,393 Project Grant (CFDA 93.866) to Yale University to examine the role of kynurenic acid in age-related cognitive deficits. The 3-year grant, starting September 1, 2023, will study how increased kynurenine inflammatory signaling with aging impairs higher cortical function in the dorsolateral prefrontal cortex (DLPFC) through blockade of NMDAR and α7-nAChR receptors, leading to working memory deficits. The research will test strategies to...
This Project Grant from the National Institutes of Health National Institute on Aging provides $4,489,362 to Duke University from September 15, 2022 through August 31, 2025 under the Aging Research program (CFDA 93.866). The grant will fund research to identify mechanisms of blood-brain barrier dysfunction in delirium superimposed on dementia after surgery. Specifically, the researchers will characterize how the postoperative systemic environment impacts the blood-brain barrier using...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to examine how high-resolution diffusion imaging can provide new insights into age-related changes in white matter connectivity and their impact on cognitive function and brain network dynamics. The $300,892 award to Duke University, which runs from October 2024 through April 2027, will support research across three aims: 1) comparing standard and high-resolution diffusion imaging...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), is focused on advancing the understanding of attentional resilience in older adults, particularly in the context of delirium and Alzheimer's disease. The $3,871,366 award to Duke University, spanning from August 2024 to April 2029, will evaluate the neural mechanisms underlying attentional control and how they contribute to maintaining cognitive function despite physiological stressors such as surgery-induced neuroinflammation or Alzheimer's-related neurodegeneration. The key objectives are to elucidate the neural processes, including EEG alpha power attenuation and sensory processing enhancement, that enable some older adults to retain robust attentional control and cognitive resilience, while others do not. This work aims to identify potential neural targets for future interventions to address delirium and dementia.