This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $320,000 to the University of Texas Medical Branch at Galveston to conduct research on the role of tau protein and alternative polyadenylation (APA) in Alzheimer's disease. The study aims to comprehensively profile APA transcripts and gene expression in neurons expressing wild-type and mutant tau proteins, with the goal of better understanding how tau oligomerization impacts APA and...
This $519,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 2-year research study by the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco. The study aims to explore the underlying molecular mechanisms by which reducing levels of the tau protein can prevent or diminish excitation/inhibition imbalance and network hyperexcitability in the brain. This imbalance has been observed in various...
This $408,638 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the effect of trans-synaptic spread of pathogenic tau protein from the entorhinal cortex to the hippocampus in Alzheimer's disease (AD) and other neurodegenerative conditions. The 2-year project at Virginia Commonwealth University will use adeno-associated viral vectors, immunofluorescence, and cellular electrophysiology to monitor tau spread and assess its...
This federal Project Grant award, R21AG089708, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866). The $1,100,000 grant supports research to investigate the mechanisms by which amyloid-beta (Aβ) modulates the binding and internalization of pathological tau oligomers within human synapses, a key component of tau pathology spreading in Alzheimer's disease. The research aims to document previously unknown synaptic mechanisms that influence tau...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD). The project aims to develop new...
This National Institute on Aging Federal Grant Award under the Aging Research program (CFDA 93.866) provides $385,000.00 to Wayne State University to investigate the role of local protein synthesis in tau pathology and neurodegeneration related to Alzheimer's disease. The project aims to determine how pathogenic forms of the tau protein specifically interfere with dendritic protein synthesis, which may contribute to the synaptic dysfunction observed in Alzheimer's disease. By leveraging tau...
This $2,919,399 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a comprehensive study led by the University of Texas Health Science Center at San Antonio (UTHSCSA) to investigate the relationships between cerebral tau deposition, cerebrovascular disease, and cognitive decline in Mexican American older adults across the Alzheimer's disease continuum. The key deliverables include: Validating traditional and novel tau PET imaging biomarkers...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $757,027 to the University of Washington to conduct research on the mechanisms underlying the synergistic relationship between tau and TDP-43 proteins in Alzheimer's disease (AD). The 5-year project, starting January 1, 2025, aims to investigate how the combination of tau and TDP-43 pathologies impairs the lysosomal autophagy pathway, which is a compensatory mechanism observed in AD. The...
This $2,061,909 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Weill Medical College of Cornell University supports research on tau proteostasis and chaperone complexes in tauopathies, including Alzheimer's disease. The objective is to identify molecular mechanisms regulating tau aggregation and neurodegeneration, specifically examining how two chaperone complexes - the "foldase" complex that stabilizes tau and the...
This $1,542,972 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research into the mechanisms underlying the link between mitochondrial dysfunction, oxygen toxicity, and tau hyperphosphorylation in neurodegenerative diseases such as Alzheimer's disease and related dementias. The project, led by the University of Cincinnati, aims to characterize tau pathology and the role of the tau kinase GSK3B in mitochondrial disease models, as...