This $1,483,884 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the role of double-stranded RNA (dsRNA) accumulation in the neuropathology of Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). The principal investigator is conducting studies to: 1) identify the RNA species contributing to dsRNA accumulation in patient brain tissues, 2) validate the specific transcripts involved, 3) determine the cellular distribution of dsRNA, and 4) establish the association between dsRNA and classic neurodegenerative disease pathologies like amyloid, TDP-43, and tau. The research team is utilizing techniques like dsRNA immunoprecipitation, RNA sequencing, and immunofluorescent staining to achieve these objectives. A $1,565,488 sub-award to Mayo Clinic Jacksonville is supporting tissue sample collection, genetic analyses, and other research activities as part of this project.
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